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Special Issue "Myeloid Cells: Multi-Functional Regulators of Immune Suppression and Tumor Progression"
Deadline for manuscript submissions: 31 October 2019.
Prof. Dr. Ali S. Arbab Website E-Mail
Tumor Angiogenesis laboratory, Georgia Cancer Center, Department of Biochemistry and Molecular Biology, Augusta University, Augusta, GA 30912, USA
Interests: glioblastoma, tumor microenvironment, neovascularization, anti-angiogenic therapy, vascular mimicry, myeloid derived supressor cells, stem cell tracking, cancer imaging
Accumulating evidence suggests that tumour-induced immune cells of myeloid origin differentiate into cells that promote tumour growth and invasion in addition to their immunosuppressive role. Although myeloid-derived suppressor cells (MDSC) were initially identified in cancer patients and mouse models due to their potent immune-suppressive activity, they are now being implicated in the promotion of tumour metastasis by participating in the formation of pre-metastatic niches, angiogenesis and invasion. MDSCs are heterogeneous populations of immature myeloid cells that include monocytic (mMDSC) and granulocytic (gMDSC) subsets, both of which have been shown to be immune-suppressive. However, molecular, biochemical and functional characterizations of the MDSCs in preclinical and clinical settings remain to be explored. Furthermore, the fact that MDSCs are major impediments in conventional as well as targeted therapies provided a compelling rationale to develop and design alternative strategies to target MDSCs.
In this Special Issue of IJMS, editors invite authors to submit work which involves the molecular, biochemical and functional characterization of MDSCs in preclinical and clinical settings. In addition, we invite studies that explore the development and design of targeted therapeutics against MDSCs.
Prof. Dr. Ali S. Arbab
Prof. Dr. Hasan Korkaya
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- myeloid cells
- MDSC subsets
- immune modulator
- tumor Microenvironment and MDSC
- vasculogenic myeloid cells
- MDSC and metastasis
- tumor plasticity