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Int. J. Mol. Sci. 2018, 19(8), 2357; https://doi.org/10.3390/ijms19082357

Myeloid-Derived Suppressor Cells as a Regulator of Immunity in Organ Transplantation

Department of Organ Transplantation and General Surgery, Kyoto Prefectural University of Medicine, Kyoto 602-8566, Japan
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Received: 25 July 2018 / Accepted: 8 August 2018 / Published: 10 August 2018
(This article belongs to the Section Biochemistry)
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Abstract

Regulation of allo-immune responses is proposed as a topic for investigation in the current field of organ transplantation. As a regulator, regulatory T cells (Tregs) have received attention due to their ability to control allograft rejection. Concurrently, however, the independent action of Tregs is not enough to achieve tolerance status in many situations. Meanwhile, as a multi-functional regulator, myeloid-derived suppressor cells (MDSCs) can suppress effector T cells as well as induce Tregs or regulatory B cells (Bregs) in certain circumstances. Furthermore, the importance of a crosstalk between MDSCs and natural killer T cells to induce tolerance has been reported. Thus, orchestration between MDSCs, myeloid regulators, T/Bregs and other lymphoid/myeloid regulators can shed light on achieving allogeneic tolerance. Here, we review the current knowledge in terms of immunological regulatory function displayed by MDSCs in the context of organ transplantation. Ideal control of MDSCs would lead to a reduction of allograft rejection and subsequent long-term allograft acceptance. View Full-Text
Keywords: myeloid-derived suppressor cells; organ transplantation; tolerance; regulatory T cells; regulatory B cells; iNKT cells; regulatory dendritic cells; regulatory macrophages myeloid-derived suppressor cells; organ transplantation; tolerance; regulatory T cells; regulatory B cells; iNKT cells; regulatory dendritic cells; regulatory macrophages
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This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
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Nakamura, T.; Ushigome, H. Myeloid-Derived Suppressor Cells as a Regulator of Immunity in Organ Transplantation. Int. J. Mol. Sci. 2018, 19, 2357.

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