The Interplay between Metabolism and Cancer and the Adipose Tissue Communication Signals
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: closed (31 March 2021) | Viewed by 30426
Special Issue Editors
Interests: adipose tissue; growth factors; inflammation; insulin resistance; tumor–microenvironment interaction; tissue regeneration
Special Issues, Collections and Topics in MDPI journals
Interests: hypoxia; cancer; pH regulation; 3D tumor models; metastasizing; adrenergic receptor signaling
Special Issue Information
Dear Colleagues,
A growing body of evidence points out to Metabolism and Cancer as tightly inter-related events. Many topics, however, need to be included in the interplay between Metabolism and Cancer. First, environmental cues should be considered. Indeed, environmental modifications may deeply affect cancer development and progression, by either impinging on initial phases of cellular transformation or changing cell trajectories toward aggressiveness. In both cases, environmental factors modify cancer cell metabolism. On the other end, metabolic perturbations are growing causes of disease. Individuals with “common” metabolic diseases, including diabetes and obesity, have increased risk of several forms of cancer. Based on the peculiar immune-metabolic features, the adipose tissue is a prime suspect for its active part in cancer and “metabolic” comorbidities. An important challenge will be to decipher the signals of the bi-directional communication between cancer and adipose tissue, being the latter one of the main component at the cancer site.
Thus, the content of the special issue will aim to clarify the following open questions:
- How macro- and micro-environmental modifications may contribute to cancer development and to adipose signals;
- How cancer cell metabolism is relevant for cancer cell fate and outcome;
- How cancer cells affect metabolic features of surrounding cells and overall metabolism;
- How cancer cells and adipose tissue exchange information and communications.
Prof. Pietro Formisano
Guest Editor
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Keywords
- diabetes
- obesity
- glucose metabolism
- lipid metabolism
- adipose tissue
- cancer progression
- inflammation
- adipokines
- exosomes
- tumor microenvironment
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