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Special Issue "Lipidomics and Neurodegenerative Diseases"
Deadline for manuscript submissions: closed (31 December 2019).
Interests: MALDI mass spectrometry; liquid chromatography; novel food; food lipidomics; proteomics
Interests: Tandem mass spectrometry; SQDG; pro-drugs; signaling molecules
Lipidomics is a targeted approach focusing on the comprehensive analysis of all lipids in biological systems. The development of soft ionization techniques, such as electrospray (ESI) and matrix-assisted laser desorption ionization (MALDI) mass spectrometry (MS), has greatly enhanced the development and application of lipidomics.
Facing lipidomic analysis by MS offers both the understanding of the definite functions of lipid species in health and disease and allows the identification of potential biomarkers for establishing protective and/or therapeutic programs for human disease.
Lipid metabolism may be of great importance for the nervous system, which represents the second highest concentration of lipids, surpassed only by the adipose tissue. The crucial role of lipids in cell signaling and tissue physiology is demonstrated by numerous neurological disorders (e.g., bipolar disorders, schizophrenia, neurodegenerative diseases such as Alzheimer’s, Parkinson’s, and Niemann–Pick diseases) in which lipid metabolism is dysregulated. Lipidomic analyses may provide powerful tools to elucidate the specific roles of lipids and their intermediates in cell signaling and open new opportunities for drug development.
This Special Issue focuses on the recent advancements in lipidomic technologies including sample preparation, direct-infusion ESI–MS and ESI–MS/MS, LC coupled with ESI–MS or MS/MS, MALDI and advanced molecular imaging techniques for their selected applications in neurodegenerative diseases.
Prof. Dr. Cosima damiana Calvano
Prof. Dr. Tommaso Cataldi
Prof. Dr. Ilario Losito
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.