Next Article in Journal
Seed Treatment with Trichoderma longibrachiatum T6 Promotes Wheat Seedling Growth under NaCl Stress Through Activating the Enzymatic and Nonenzymatic Antioxidant Defense Systems
Next Article in Special Issue
Lipid and Lipid Raft Alteration in Aging and Neurodegenerative Diseases: A Window for the Development of New Biomarkers
Previous Article in Journal
Angiogenesis, Lymphangiogenesis, and the Immune Response in South African Preeclamptic Women Receiving HAART
Previous Article in Special Issue
Alteration of Sphingolipids in Biofluids: Implications for Neurodegenerative Diseases
Review

Evaluation of the Common Molecular Basis in Alzheimer’s and Parkinson’s Diseases

1
Department of Computer Science, Virginia Commonwealth University, Richmond, VA 23284, USA
2
Institute of Biological Sciences, Federal University of Para, Belem-PA 66075-110, Brazil
3
Centre for Genomics and Applied Gene Technology, Institute of Integrative Omics and Applied Biotechnology (IIOAB), Nonakuri, Purba Medinipur, West Bengal 721172, India
4
Institute of Biological Science, Federal University of Minas Gerais, Belo Horizonte-MG 31270-901, Brazil
*
Author to whom correspondence should be addressed.
Current address: Virginia Commonwealth University, Department of Computer Science, Richmond, VA 23284, USA.
Int. J. Mol. Sci. 2019, 20(15), 3730; https://doi.org/10.3390/ijms20153730
Received: 14 June 2019 / Revised: 23 July 2019 / Accepted: 23 July 2019 / Published: 30 July 2019
(This article belongs to the Special Issue Lipidomics and Neurodegenerative Diseases)
Alzheimer’s disease (AD) and Parkinson’s disease (PD) are the most common neurodegenerative disorders related to aging. Though several risk factors are shared between these two diseases, the exact relationship between them is still unknown. In this paper, we analyzed how these two diseases relate to each other from the genomic, epigenomic, and transcriptomic viewpoints. Using an extensive literature mining, we first accumulated the list of genes from major genome-wide association (GWAS) studies. Based on these GWAS studies, we observed that only one gene (HLA-DRB5) was shared between AD and PD. A subsequent literature search identified a few other genes involved in these two diseases, among which SIRT1 seemed to be the most prominent one. While we listed all the miRNAs that have been previously reported for AD and PD separately, we found only 15 different miRNAs that were reported in both diseases. In order to get better insights, we predicted the gene co-expression network for both AD and PD using network analysis algorithms applied to two GEO datasets. The network analysis revealed six clusters of genes related to AD and four clusters of genes related to PD; however, there was very low functional similarity between these clusters, pointing to insignificant similarity between AD and PD even at the level of affected biological processes. Finally, we postulated the putative epigenetic regulator modules that are common to AD and PD. View Full-Text
Keywords: Alzheimer’s disease; Parkinson’s disease; genetics; gene regulatory network; miRNAs Alzheimer’s disease; Parkinson’s disease; genetics; gene regulatory network; miRNAs
Show Figures

Figure 1

MDPI and ACS Style

Rana, P.; Franco, E.F.; Rao, Y.; Syed, K.; Barh, D.; Azevedo, V.; Ramos, R.T.J.; Ghosh, P. Evaluation of the Common Molecular Basis in Alzheimer’s and Parkinson’s Diseases. Int. J. Mol. Sci. 2019, 20, 3730. https://doi.org/10.3390/ijms20153730

AMA Style

Rana P, Franco EF, Rao Y, Syed K, Barh D, Azevedo V, Ramos RTJ, Ghosh P. Evaluation of the Common Molecular Basis in Alzheimer’s and Parkinson’s Diseases. International Journal of Molecular Sciences. 2019; 20(15):3730. https://doi.org/10.3390/ijms20153730

Chicago/Turabian Style

Rana, Pratip, Edian F. Franco, Yug Rao, Khajamoinuddin Syed, Debmalya Barh, Vasco Azevedo, Rommel T.J. Ramos, and Preetam Ghosh. 2019. "Evaluation of the Common Molecular Basis in Alzheimer’s and Parkinson’s Diseases" International Journal of Molecular Sciences 20, no. 15: 3730. https://doi.org/10.3390/ijms20153730

Find Other Styles
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop