Roles of Cardiovascular Active Substances and Cellular Events in the Homeostasis of Cardiovascular Systems

Dear Colleagues,

Cardiovascular active substances contribute to the maintenance of cardiovascular homeostasis. Conversely, disturbances might potentially induce cardiovascular diseases (CVDs). For example, continuous production of endothelium-derived substances, including nitric oxide and vasodilating prostanoids, is protective against CVDs, such as hypertension, atherosclerosis, and ischemic CVDs, while the increased production of endithelium-derived substances, including constrictive prostanoids and endothelin-1, potentially promote CVDs. Thus, the balance of cardiovascular active substances is very important for the maintenance of cardiovascular homeostasis. In addition to such classical substances, many other novel cardiovascular active substances, such as adipocyte-derived cytokine (adipocytokine) and matricryptins (active fragments of extracellular matrix), have been identified. Moreover, cellular events, including endoplasmic reticulum stress, mitochondrial dysfunction, and apoptosis induced by the abovementioned substances or inflammation, also play important roles in the development of CVDs. In this Special Issue, we aim at collecting current knowledge of those cardiovascular active substances and cellular events, summarize their mechanisms of actions, on both cardiovascular physiology and pathophysiology, and explore their potential applications in the treatment and diagnosis of CVDs.

Prof. Dr. Hideyuki Yamawaki
Dr. Takayuki Matsumoto
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 250 words) can be sent to the Editorial Office for assessment.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.