Endometriosis and Uterine Fibroids: From Molecular Biology to Therapy

Dear Colleagues,

This Special Issue entitled “Endometriosis and Uterine Fibroids: From Molecular Biology to Therapy” will comprise a selection of novel research articles.

Endometriosis affects up to ten percent of women of reproductive age and causes symptoms that include different chronic pelvic pain manifestations and infertility. The therapeutic strategies include surgical resection of ectopic lesions, pain management, and different hormonal treatments. At present, some subtypes of this benign disease can only be diagnosed by laparoscopy, as a valid non-invasive diagnostic marker has not yet been established.

Uterine fibroids are the most common gynecological disease. Symptoms include heavy menstrual bleeding, bloating, anemia, pelvic pain, and subfertility. In addition to symptomatic therapy and surgical removal of these benign tumors, the goal of recent research focuses on hormonally induced reduction of size and consequent improvement of individual symptoms.

As both diseases (endometriosis and uterine fibroids) are estrogen-dependent, many therapeutic strategies are based on hormonal agents and are similar for both diseases. To date, our therapeutic armamentarium has not been dramatically improved over the last decades. This is based on the fact that the etiology and pathophysiology of endometriosis and uterine fibroids have not been completely elucidated. A better understanding of these mechanisms could lead to new therapeutic options.

All contributions, either review, meta-analysis, or original research articles related to our topic “Endometriosis and Uterine Fibroids: From Molecular Biology to Therapy”, are welcome for submission in this Special Issue of the International Journal of Molecular Sciences.

Prof. Dr. René Wenzl
Dr. Alexandra Perricos
Guest Editors

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