Centenarians—a Model to Study the Molecular Basis of Lifespan and Healthspan 2.0

Dear Colleagues,

The extraordinary rise in the older population in the Western world underscores the importance of studies on ageing and longevity to decrease the medical, economic, and social problems associated with the increased number of non-autonomous individuals affected by invalidating pathologies.

Centenarians show relatively good health, being able to perform their routine daily life and to escape or delay age-related diseases. This Special Issue aims to understand, through a “positive biology” approach, how to prevent, reduce, or delay frailty and disability amongst the older. Indeed, rather than making diseases the central focus of study, “positive biology” seeks to understand the causes of positive phenotypes and explain the biological mechanisms of health and immunosenescence.

In this Special Issue, studies on different aspects of centenarians are welcome.

Original research papers and reviews are equally welcome and may involve in vitro and in vivo studies in different cells and organisms.

Prof. Dr. Calogero Caruso
Prof. Dr. Annibale Puca
Guest Editors

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