Cancer Metabolism—Metabolites Regulation of Oncogenic Signaling and Epigenetics

Dear Colleagues,

This Special Issue focuses on mechanisms and regulations in the altered metabolic pathways in cancer cells.

Cancer has been considered a disorder of proliferation, but recent evidence suggests that cancer is also a metabolic disease. The fact that growing tumors rewire their metabolic programs was first recognized almost a century ago. Now, links between oncogenic pathways and cancer-cell metabolism have been established. Cancer cells alter their metabolism to meet their energetic and anabolic demands and to survive in hostile environments.

The cancer metabolome is extremely flexible, creating challenges for drug discovery, as cancers can often bypass the effects of a small molecule by shifting pathways. A better understanding of cancer-specific metabolic processes may revolutionize cancer treatment.

Metabolic remodeling in cancer creates metabolites that control the signaling and epigenetic pathways that drive tumors. Understanding the interaction between metabolism and signaling/epigenetic pathways could reveal new vulnerabilities of cancer.

We welcome submissions, including original manuscripts and reviews, on this important topic.

Dr. Jun-ichi Hanai
Guest Editor

Manuscript Submission Information

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