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Special Issue "Cancer Metabolism—Metabolites Regulation of Oncogenic Signaling and Epigenetics"
Deadline for manuscript submissions: 31 January 2020.
Interests: oncogenic stem cells; EMT (epithelial mesenchymal transition); fibrosis; vascular pathology; aging
Special Issues and Collections in MDPI journals
This Special Issue focuses on mechanisms and regulations in the altered metabolic pathways in cancer cells.
Cancer has been considered a disorder of proliferation, but recent evidence suggests that cancer is also a metabolic disease. The fact that growing tumors rewire their metabolic programs was first recognized almost a century ago. Now, links between oncogenic pathways and cancer-cell metabolism have been established. Cancer cells alter their metabolism to meet their energetic and anabolic demands and to survive in hostile environments.
The cancer metabolome is extremely flexible, creating challenges for drug discovery, as cancers can often bypass the effects of a small molecule by shifting pathways. A better understanding of cancer-specific metabolic processes may revolutionize cancer treatment.
Metabolic remodeling in cancer creates metabolites that control the signaling and epigenetic pathways that drive tumors. Understanding the interaction between metabolism and signaling/epigenetic pathways could reveal new vulnerabilities of cancer.
We welcome submissions, including original manuscripts and reviews, on this important topic.
Dr. Jun-ichi Hanai
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- impact of oncogenic signaling on metabolism
- alterations in metabolite-driven gene regulation and signaling pathways
- metabolic wiring
- metabolic control of the epigenome
- metabolic heterogeneity and cancer progression
- targeting metabolic liabilities
- targeting stroma metabolism
- cancer metabolism influenced by systemic metabolic status
- redox metabolism
- the influence of metabolism on metastasis and progression
- Warburg in non-cancer diseases, inflammation
- metabolism-based imaging
- preclinical and clinical studies of metabolism-related cancer therapies