Special Issue "TGF-Beta Super Family Signaling 2.0"
Deadline for manuscript submissions: closed (31 January 2020).
Interests: oncogenic stem cells; EMT (epithelial mesenchymal transition); fibrosis; vascular pathology; aging
2. Division of Nephrology, Department of Internal Medicine, Saga University Faculty of Medicine, Saga, Japan
Interests: vascular biology; cellular plasticity; pathological stem cells; cellular senescence and aging; laminopathy; mechanotransduction; atherosclerosis; tissue fibrosis; mineral metabolism
This Special Issue is the continuation of our 2018 Special Issue, “TGF-Beta Super Family Signaling”.
Our knowledge of this superfamily is quickly expanding into previously uncharted areas of biology and human pathogenesis. TGF-β superfamily members play pivotal roles throughout development and later in adult homeostasis to orchestrate complex processes. Consistent with their diversity of function, aberrant signaling by members of the TGF-β superfamily is associated with a wide range of human pathologies, including immune system compromise, cardiovascular and fibrotic diseases, aging processes, and, critically, cancer.
The goal of this Special Issue is to broaden the molecular understanding of the key roles of TGF-β superfamily members, including TGF-βs, nodal, activins, BMPs, and GDFs in pathophysiological processes. The mechanisms of aberrations in this signaling pathway, which lead to human disease pathologies, will be especially highlighted.
Topics will include (but are not limited to) cancer biology, stem cell biology, cellular plasticity, inflammation, immune surveillance escape, stress response, tissue fibrosis, vasculature and tissue transformation (EndMT/EMT), tissue microenvironment dynamics, and therapeutic frontiers of TGF-β signaling.
Up-to-date review articles and experimental papers are all welcome. We look forward to your contributions.
Dr. Jun-ichi Hanai
Dr. Noriko Ide
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
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- Signaling crosstalk
- Immune and inflammatory response
- Stress response
- Tissue morphogenesis and plasticity
- Oncogenic stem cells (cancer initiating cells)
- Tissue microenvironment dynamics
- Tissue fibrosis
- Epigenetic regulation
- Therapeutic frontiers