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Special Issue "Calmodulin Function in Health and Disease"
Deadline for manuscript submissions: closed (31 December 2019).
Interests: Calcium signaling; cancer biology; cell migration; cell proliferation; ErbB/HER receptors; Grb7 adaptor proteins; phospho-calmodulin; Src family kinases
Calmodulin is the major intracellular transducer of the Ca2+ signal in all eukaryotic cells, regulating a myriad of cellular processes by modulating the activity of hundreds of proteins, including enzymes, ion channels, transcription factors, receptors for different ligands, adaptors and structural proteins. The multifunctional role of this highly conserved protein is facilitated by its capacity to utilise different occupancy of its four Ca2+-binding sites with distinct affinities and binding kinetics, and its enormous structural flexibility. This allows for simultaneous linkage to distinct or identical proteins and/or two segments of the same protein, forming dimeric complexes or operational motifs with specific functional roles. Post-translational modifications of calmodulin, particularly its phosphorylation, add an additional layer of complexity to the functionality of calmodulin, allowing for drastic modification or subtle modulation of its multiple regulatory roles. In recent years, the discovery of calmodulin mutations in humans has uncovered its critical role in cardiac physiology and enabled new insights into the cause of different types of cardiac arrhythmias. These genetic alterations could be the cause of yet uncovered pathologies. It is expected that the study of calmodulin functionality in health and its dysfunction in disorders, including cancer, could help to identify new potential pharmacological targets to combat different diseases.
Prof. Dr. Antonio Villalobo
Prof. Dr. Martin W. Berchtold
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Ca2+-dependent calmodulin functions
- Ca2+-independent calmodulin functions
- Posttranslational calmodulin modifications
- Calmodulin genetics
- Calmodulin mutations
- Calmodulin as adaptor
- Calmodulin-based Ca2+ sensors
- Calmodulin inhibitors
- Calmodulin biophysics
- Calmodulin in health and disease
- Calmodulin evolution