Special Issue "Biofilm Formation"
Deadline for manuscript submissions: closed (5 April 2018).
Interests: pseudomonas aeruginosa; quorum sensing; biofilms; virulence; metabolism; protein chemistry
Although the tendency of bacteria to attach to solid surfaces has been known about for many decades, it is fair to say that most bacteria spend most of their time in a biofilm-associated state. The last twenty years have witnessed an explosion of interest in this area. This has been largely driven by the notion that such biotic–abiotic interactions are not accidental, but instead, are governed by distinct “lifestyle decisions” driven by programmed changes in gene expression profiles. These, in turn, are now known to be underpinned by dedicated signaling pathways, which respond to environmental signals and cues. Moreover, it is becoming increasingly apparent that bacteria—once viewed as the archetypal single-celled organisms—benefit from social interactions within biofilms. Indeed, biofilms are now thought of as structured multicellular communities in which resources are shared (albeit, not always altruistically) and the response to existential threats is collective. This improved understanding of biofilm biology has become increasingly important, especially with the realization that biofilm formation is strongly-linked with greater antibiotic resistance and the onset of chronic infection. Consequently, finding new ways of suppressing biofilm formation by pathogenic bacteria has become an international priority.
Dr. Martin Welch
Manuscript Submission Information
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- quorum sensing
- cell-cell communication
- chronic infection
- antibiotic resistance
- microbial communities
- programmed gene expression