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Special Issue "Targeted Protection of Bioactive Compounds to Mitochondria"
Deadline for manuscript submissions: closed (31 October 2019).
Mitochondria play a key role in many cellular processes and can rapidly adapt to meet the metabolic needs of a cell in response to change in environmental condition. Their dysfunction has been related to metabolic disease associated with obesity, such as insulin resistance, diabetes, cardiovascular disease, cancer and neurodegenerative disease. It has been also shown that mitochondrial function is strictly related to their dynamic behaviour in terms of balance of fusion and fission processes. Mitochondrial impairment results in the removal of damaged mitochondria through fission and mitophagy, whereas the fusion of individual mitochondria into dynamic network is associated with improvement of mitochondrial function.
This Special Issue is focused on the protective effects of bioactive compounds on mitochondrial bioenergetics and dynamic behaviour. Different bioactive compounds have been shown to improve mitochondrial function and dynamic behaviour, counteracting cellular damage, tissue dysfunction and metabolic diseases. The submission of original research articles or reviews related to the targeted protection of bioactive compounds to mitochondria is encouraged. It is particularly encouraged the submission of manuscript focused on clarify at the cellular and molecular level, the role of bioactive compounds in regulating interaction between mitochondria and the others intracellular components, such as endoplasmic reticulum and nucleus, as well as their impact into the interplay between mitochondrial bioenergetics, reactive oxygen species production and inflammatory pathways in the frame of the new concept of metaflammasome. Understanding how bioactive compounds may improve mitochondrial bioenergetics and metabolic adaptation at the cellular and molecular level, has the potential to generate new knowledge that will lead to improved treatment or protection towards many of the metabolic diseases that characterize modern societies.
Prof. Dr. Lillà Lionetti
Prof. Dr. Assunta Lombardi
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- bioactive compounds
- mitochondrial bioenergetics
- mitochondrial fusion
- mitochondrial fission
- ROS production
- metabolic diseases