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Special Issue "Advances in Bcl-xL Research"
Deadline for manuscript submissions: closed (31 October 2019).
The oncogene Bcl-xL is an anti-apoptotic member of the Bcl-2 family that was established as a major survival factor in erythroid lineage and neuronal cells. More recently, Bcl-xL also emerged as being responsible for the resistance of malignant tumor cells to anti-cancer treatments. Over the last decade, refined description of its regulation revealed that several mechanisms are at work that make Bcl-xL instrumental in the control of survival, proliferation, and differentiation. These mechanisms comprise post-translational modifications, the dynamic interactions this protein establishes with its target membranes, and also its interactions with binding partners within and outside the Bcl-2 family of proteins. This Special Issue of IJMS will focus on how Bcl-xL is regulated at the protein level, its organization in the membrane, the plasticity of its interactome, and how it warrants a diversity of cellular functions controlled by Bcl-xL in physiology and pathology. Articles submitted can either provide a review of specific points of the literature, or be original works offering significant advances in the structure and functions of Bcl-xL.
Dr. Muriel Priault
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Survival, proliferation, and differentiation
- Mechanisms of tumor progression
- Mitochondria/endoplasmic reticulum interplay
- Membrane insertion/protein oligomerization
- Targeted drug design