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BCL-xL, a Mitochondrial Protein Involved in Successful Aging: From C. elegans to Human Centenarians

1
Freshage Research Group, Department of Physiology, Faculty of Medicine, University of Valencia, CIBERFES, INCLIVA, Avenida Blasco Ibañez, 15 46010 Valencia, Spain
2
Freshage Research Group, Department of Physiotherapy, Faculty of Physiotherapy, University of Valencia, CIBERFES, INCLIVA, Avenida Blasco Ibañez, 15 46010 Valencia, Spain
*
Author to whom correspondence should be addressed.
These authors have contributed equally to the manuscript.
Int. J. Mol. Sci. 2020, 21(2), 418; https://doi.org/10.3390/ijms21020418
Received: 4 December 2019 / Revised: 1 January 2020 / Accepted: 4 January 2020 / Published: 9 January 2020
(This article belongs to the Special Issue Advances in Bcl-xL Research)
B-Cell Lymphoma-extra-large (BCL-xL) is involved in longevity and successful aging, which indicates a role for BCL-xL in cell survival pathway regulation. Beyond its well described role as an inhibitor of apoptosis by preventing cytochrome c release, BCL-xL has also been related, indirectly, to autophagy and senescence pathways. Although in these latter cases, BCL-xL has dual roles, either activating or inhibiting, depending on the cell type and the specific conditions. Taken together, all these findings suggest a precise mechanism of action for BCL-xL, able to regulate the crosstalk between apoptosis, autophagy, and senescence, thus promoting cell survival or cell death. All three pathways can be both beneficial or detrimental depending on the circumstances. Thus, targeting BCL-xL would in turn be a “double-edge sword” and therefore, additional studies are needed to better comprehend this dual and apparently contradictory role of BCL-XL in longevity. View Full-Text
Keywords: healthy aging; apoptosis; autophagy; senescence; longevity; mitochondria healthy aging; apoptosis; autophagy; senescence; longevity; mitochondria
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Borrás, C.; Mas-Bargues, C.; Román-Domínguez, A.; Sanz-Ros, J.; Gimeno-Mallench, L.; Inglés, M.; Gambini, J.; Viña, J. BCL-xL, a Mitochondrial Protein Involved in Successful Aging: From C. elegans to Human Centenarians. Int. J. Mol. Sci. 2020, 21, 418.

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