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Special Issue "The Actin-Myosin Interaction in Muscle"
Deadline for manuscript submissions: closed (19 October 2018).
Interests: myosin filament structure; actin filament structure and regulation; muscle contractile mechanism; sarcomere structure; M-band structure; Z-band structure; titin properties and interactions; muscle sarcomere evolution
Research into the mechanism of muscle contraction has reached an intriguing stage. A great deal is known about the structures of the various components that, together, form the muscle contractile machinery. The structures of myosin heads and myosin and actin filaments are fairly well understood at quite high resolutions, as are the geometries of interaction of myosin heads with actin under a variety of conditions. However, in answer to the question ‘how is muscular force actually produced?’, we have to acknowledge that there are still great uncertainties in relating what we know about muscle structure to the observed physiological behaviour of different muscles. Additionally, how do different mutations in the proteins of the contractile machinery affect how muscles actually work?
The aim of the present Special Issue is to bring together reviews and original papers on the actual mechanism of contraction as understood from a variety of approaches. We are looking for papers or reviews in three main areas: (1) original papers or reviews on what is known about myosin head structures and the way that myosin heads interact with actin; (2) original papers or reviews on the dynamics of myosin crossbridge behaviour in active muscle; and (3) original papers or reviews on the ways that known disease-associated mutations in the various thick and thin filament proteins, including the myosin head, affect the contractile cycle.Prof. Dr. John Squire
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.