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New Research on Bioactive Natural Products

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 31 August 2024 | Viewed by 762

Special Issue Editor

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Guest Editor
Hephaestus Laboratory, Department of Chemistry, School of Science, Democritus University of Thrace, Kavala University Campus, St Lucas, GR 65404 Kavala, Greece
Interests: inflammation; thrombosis; oxidative stress; chronic disorders; cardiovascular disoases; cancer; renal disorders; neurodegenerative disorders; persistent infections; anti-inflammatory; antithrombotic; antioxidant; cardio-protective; antitumor; antidiabetic; skin protection; anti-ageing; anti-UV protection; natural bioactives; bioactives; bioactive compounds; bioactive ingredients; valorization of by-products; phenolics; polar lipids; vitamins; functional foods; supplements; nutraceuticals; drugs; cosmetics
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Special Issue Information

Dear Colleagues,

Chronic disorders like cardiovascular diseases (CVD), cancer, renal and neurodegenerative disorders, allergy and autoimmune diseases, persistent infections and associated manifestations, etc., are a global burden. Even though current approaches for prevention and therapy have high efficacy, they nevertheless usually come along with high costs, undesirable side effects and environmental issues. Hence, there is an increasing necessity for developing novel products containing natural bioactives, especially those derived from sustainable natural sources.

The objective of this Special Issue is to promote research in the field and outline the current status and future perspectives on the valorization of bioactives from sustainable natural sources, such as the rich-in-natural-bioactives bio-cultures of several microorganisms and/or several by-products of the agro-food sector, as well as to highlight their importance as ingredients for the design and production of high-value, bio-functional medicinal products, including supplements, nutraceuticals and drugs, with promising health-promoting effects, against the aforementioned inflammation-related chronic disorders. Emphasis will be given to work with state-of-the-art methods of isolation and molecular analysis applied to several natural sources for obtaining/extracting and fractionating such natural micro-/macro-bioactives from the prime extracts/mixtures/filtrates/isolates/etc. derived from a sustainable natural source, as well as to the OMICS-based full chemical characterization and structural elucidation, in tandem with designed and tailored bioassays and in vitro/ex vivo/in vivo approaches, in order to evaluate structure–activity relationships and potential synergism(s) against specific bio-molecular pathways and cell/tissue/organ biological responses, which is of paramount importance in assessing structure–activity and causality, and will provide the molecular evidence for the utilization of the most optimum bio-functional natural bioactives or their mixtures for the production of targeted bio-functional products, based on current legislations and according to the needs of the industry and consumers.

Studies containing such targeted biomolecular experiments accompanied by appropriately designed approaches for evaluating the clinical safety and efficacy of products containing such natural bioactives, through tandem animal studies and clinical trials, are also welcomed. Special attention will be given to work on such sustainable natural bioactives with higher safety, efficacy and bioavailability–biodigestibility. Finally, relative reviews and meta-analysis articles in the field are also welcomed in this Special Issue.

Dr. Alexandros Tsoupras
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.


  • chronic disorders
  • bioactives
  • natural sources
  • sustainable sources
  • biomolecular
  • structure–activity relationship
  • synergism
  • health promoting
  • bio-functional
  • products
  • supplements
  • nutraceuticals
  • drugs

Published Papers (1 paper)

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19 pages, 5939 KiB  
Antimicrobial Properties of Flavonoid Derivatives with Bromine, Chlorine, and Nitro Group Obtained by Chemical Synthesis and Biotransformation Studies
by Martyna Perz, Daria Szymanowska, Tomasz Janeczko and Edyta Kostrzewa-Susłow
Int. J. Mol. Sci. 2024, 25(10), 5540; https://doi.org/10.3390/ijms25105540 - 19 May 2024
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The search for new substances of natural origin, such as flavonoids, is necessary in the fight against the growing number of diseases and bacterial resistance to antibiotics. In our research, we wanted to check the influence of flavonoids with chlorine or bromine atoms [...] Read more.
The search for new substances of natural origin, such as flavonoids, is necessary in the fight against the growing number of diseases and bacterial resistance to antibiotics. In our research, we wanted to check the influence of flavonoids with chlorine or bromine atoms and a nitro group on pathogenic and probiotic bacteria. We synthesized flavonoids using Claisen–Schmidt condensation and its modifications, and through biotransformation via entomopathogenic filamentous fungi, we obtained their glycoside derivatives. Biotransformation yielded two new flavonoid glycosides: 8-amino-6-chloroflavone 4′-O-β-D-(4″-O-methyl)-glucopyranoside and 6-bromo-8-nitroflavone 4′-O-β-D-(4″-O-methyl)-glucopyranoside. Subsequently, we checked the antimicrobial properties of the aforementioned aglycon flavonoid compounds against pathogenic and probiotic bacteria and yeast. Our studies revealed that flavones have superior inhibitory effects compared to chalcones and flavanones. Notably, 6-chloro-8-nitroflavone showed potent inhibitory activity against pathogenic bacteria. Conversely, flavanones 6-chloro-8-nitroflavanone and 6-bromo-8-nitroflavanone stimulated the growth of probiotic bacteria (Lactobacillus acidophilus and Pediococcus pentosaceus). Our research has shown that the presence of chlorine, bromine, and nitro groups has a significant effect on their antimicrobial properties. Full article
(This article belongs to the Special Issue New Research on Bioactive Natural Products)
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