Metabolic Enzymes of Thrombo-Inflammatory and Oxidative Stress Mediators in Health and Disease
A special issue of Catalysts (ISSN 2073-4344). This special issue belongs to the section "Biocatalysis".
Deadline for manuscript submissions: 15 May 2025 | Viewed by 937
Special Issue Editors
Interests: inflammation; thrombosis; chronic disorders; anti-inflammatory bioactives; antioxidants
Special Issues, Collections and Topics in MDPI journals
Interests: anti-inflammatory; antithrombotic; antiplatelet; bioactives; bioanalytical chemistry
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Inflammation, thrombosis and oxidative stress are implicated in several physiological processes; but, if dysregulated and thus unresolved, then according to the WHO and the current literature, these processes can lead to unfavorable pathological manifestations and associated disorders. Specific mediators, the levels of which are tightly regulated by specific enzyme machinery, are involved in the main signaling cascades of these processes. The main regulatory enzymes for the synthesis and/or catabolism of important thrombo-inflammatory mediators are affected by the disease state and can thus can either increase and prolong the levels of the mediators they synthesize and/or they can decrease or cause the withdrawal of these/other mediators involved. As with other biological processes, the dynamic aspects of the biochemistry of enzymes that interfere in the inflammation process are complicated and thus they require further evaluation and, in some cases, thorough re-assessment.
The aim of the specific Special Issue is to shed light on the current status, advances, interactions, conflicts and future perspectives of the roles of inducible enzymes in health and disease that are involved in inflammation, thrombosis and oxidative stress, such as several pro-inflammatory enzymes like cyclooxygenase (COX) and lipoxygenase (LOX) that induce synthesis from arachidonic acid (AA)-derived bioactive lipids, prostanoids and leukotrienes, respectively, collectively called eicosanoids. These are targets for several non-steroidal anti-inflammatory drugs/pharmaceuticals, as well as nitric oxide synthase (iNOS), aldo-keto reductases (AKRs), glutathione transferases (GSTs), metalloproteinases (MMPs) and several other pro-/anti-inflammatory enzymes like the synthetic and catabolic enzymes of several other important thrombo-inflammatory mediators like platelet activating factor (PAF)—the dysregulation of which is involved in several pathological situations. There are also pro-oxidant and/or antioxidant enzymes involved in oxidative stress-related manifestations like superoxide dismutase (SOD), glutathione peroxidase (GPX), catalase (CAT), nitric oxide synthase (eNOS, iNOS, and nNOS), peroxiredoxins, thioredoxins (Trx), and more.
Research articles, comprehensive and/or critical, and/or systematic reviews and meta-analysis studies on the above are welcomed to be submitted to this interesting Special Issue.
Dr. Alexandros Tsoupras
Dr. Anna Ofrydopoulou
Guest Editors
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. Catalysts is an international peer-reviewed open access monthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. The Article Processing Charge (APC) for publication in this open access journal is 2200 CHF (Swiss Francs). Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
Keywords
- inflammation
- thrombosis
- oxidative stress
- metabolic enzymes
- cyclooxygenases
- regulatory enzymes
- anti-inflammatory
- antithrombotic
- antioxidant
Benefits of Publishing in a Special Issue
- Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
- Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
- Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
- External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
- e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.
Further information on MDPI's Special Issue policies can be found here.
