Impact of 3'UTR Variants on mRNA Stability
A special issue of Biomedicines (ISSN 2227-9059). This special issue belongs to the section "Gene and Cell Therapy".
Deadline for manuscript submissions: closed (31 January 2024) | Viewed by 364
Special Issue Editors
Interests: molecular medicine; predictive medicine; personalized medicine; inflammation; ncRNAs
Special Issues, Collections and Topics in MDPI journals
Interests: kidney pathology; dialysis; vascular pathology; molecular medicine; predictive medicine; personalized medicine; inflammation; ncRNAs; organs-on-chip; artificial intelligence
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Recent years have seen a huge increase in the number of works describing the nature and function of newly described regulatory RNAs. This knowledge has allowed for the delineation of complex regulatory networks that relate mRNAs’ stability to the expression of microRNAs (miRNAs) and lncRNAs (as miRNA sponges).
Additionally, a number of authors have recently described a new functional feature of mRNAs that directly impacts the establishment of these RNA regulatory networks, i.e., the dynamic expression of different 3’UTR isoforms to regulate the accession of miRNAs to their target mRNA sequences.
In this Special Issue we are interested in the mechanisms that generate 3’UTR diversity in normal and disease cells (such as alternative polyadenylation, alternative splicing, or the exonization of repetitive elements), in addition to their impact on mRNA function. Furthermore, we are also especially interested in the use of alternative 3’UTRs for the stabilization of mRNA vaccines.
We are also willing to receive originals on technical developments that have facilitated the generation as well as analysis of transcriptonic information of 3’UTR variants and their impact on mRNA stability and function:
- Development of software to extract variant 3’UTR data from RNA.seq/single-cell RNA.seq runs;
- Generation of databases of variant 3’UTRs in human diseases;
- New experimental techniques for the high-throughput targeting of mRNA–miRNA as well as miRNA–lncRNA interactions;
- Software for modeling mRNA–miRNA–lncRNA networks, including alternative 3’UTRs
Dr. Estanislao Navarro
Dr. Miguel Hueso
Guest Editors
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