Melanoma: Molecular Mechanisms and Therapy
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Oncology".
Deadline for manuscript submissions: 30 September 2024 | Viewed by 473
Special Issue Editor
Interests: human malignant melanoma; metastatic progression; genomic alterations; gene expression alterations; chromosome copy number alterations; array CGH; FISH
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Melanoma is the most aggressive form of skin cancer, with a very high capacity to metastasize to different organs. The five-year survival rate of patients with early-stage melanoma is over 98%; however, if the primary tumor has spread to distant organs, the survival rate drops to 17%. After introducing several new therapeutic strategies, the prognosis of late-state and metastatic melanomas has improved significantly during the last 10 years. Unfortunately, successful treatment of melanoma patients with distant metastases is still a major therapeutic challenge. The molecular mechanisms that underline the metastatic process into distant organs are only partially understood. After the initial success of either target (e.g., BRAF/MEK inhibitors) or immunotherapies, drug resistance develops in the majority of patients due to various heterogeneous distributions of the molecular alterations. It is imperative to further detail the molecular mechanisms underlying the progression of the disease and the molecular background of the development of drug resistance.
Prof. Dr. Balázs Margit
Guest Editor
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Keywords
- melanoma progression
- melanoma metastasis molecular background
- targeted therapy
- immunotherapy
- acquired drug resistance
- prognostic and predictive markers
- therapeutic targets
