Special Issue "Vascular Endothelial Growth Factor"
Deadline for manuscript submissions: closed (31 March 2018).
Prof. Kurt Ballmer-Hofer
A Special Issue on Vascular Endothelial Growth Factor, VEGF, is being prepared for the journal IJMS. VEGF was originally described as Vascular Permeability Factor, VPF, released by tumor tissue and later found to be the major driver of blood and lymphatic vessel development in mammals. VEGFs are derived from primordial molecules shaping the open vascular system of insects and comprise a family of four members. Additionally, functionally and structurally highly related homologues were found in pox viruses and snake venoms. The four VEGF genes in mammals give rise to a large number of functionally distinct protein isoforms that combinatorially activate three type V receptor tyrosine kinases. The dissection of the complexity of VEGF signaling is the focus of intense research and understanding VEGF signaling at the molecular level has great potential for future medical applications.
Altered functionality and expression of VEGFs and their receptors are the cause of severe human pathologies, such as retinopathies of the eye, atherosclerosis or the promotion and dissemination of cancer. Novel and more specific drugs must be developed for broad and successful application in the clinic in the future.Prof. Kurt Ballmer-Hofer
Manuscript Submission Information
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- receptor tyrosine kinase
- vascular endothelial growth factor