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Special Issue "Unraveling Pancreatic Cancer: Pathogenesis, Development, Diagnostic and Treatment"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: 31 January 2020.
Pancreatic cancer is, worldwide, the 6th most frequent cause of cancer death. The incidence of this disease is rising worldwide, especially in Asian countries. Of all cancers it has the most abysmal five-year survival rate. This is due to a lack of sufficiently early detection methods and the fact that, if detected, the cancer has already spread, even if it is locally resectable using current imaging standards. While chemotherapy has improved in recent years, medical treatment serves only to prolong the life expectancy of patients, but rarely cures. Analyzing the common genetic changes demonstrate a rather monotone set of mutations, typically in KRAS, SMAD4, TP53 and CDKN2A. This has resulted in a resurrection of the importance of an understanding of epigenetic changes and has led to the introduction of pancreatic cancer subtypes, which might need different treatment approaches. With the advent of organoid culture methods, pre-testing for chemo resistance might be feasible to adjust therapeutic regimens and can be used to establish new genetic signatures for resistance. Together with improved immunooncology approaches like genetically-engineered CAR-T cells, this knowledge of molecular changes in pancreatic cancer might considerably improve survival rates. Looking forward, the area of improvement is vast and, within this Special Issue, we would like to show novel concepts for the diagnosis and treatment of pancreatic cancer based on new molecular biology insights.
Prof. Dr. Christian Pilarsky
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- early detection