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Current Research in Antimicrobial Natural Products

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A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 20 September 2024 | Viewed by 2467

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Special Issue Editor

Dr. Jose Javier Sanz Gomez

E-Mail Website
Guest Editor

Institute of Food Science and Technology (ICTAL), La Serna 58, 24007 León, Spain
Interests: foodborne pathogens; microbiology of food; natural extract from palantas; propolis; bioactive compounds

Special Issue Information

Dear Colleagues,

There are several microorganisms which possess pathogenic traits. Due to the contamination of these pathogenic microorganisms, food safety is becoming a major concern on a global level. Annually, 33 million people are affected by foodborne illness across the globe. Many of the pathogenic microbes, on account of their exceptional surviving conditions, have a potential risk of surviving even after cleaning and sterilization processes. Therefore, they become a great risk of illness. In addition, the Food and Agriculture Organization of the United Nations carried out a study revealing that one-third (1.3 billion tons per year) of food production for human consumption is lost because of spoilage or waste. Although there is continuous development in food technology, the morbidity caused by foodborne illness, food loss, and biofilm formation are still prevailing, especially in developing countries. Both the health and economic sectors of countries worldwide suffer due to this threat. There is an increasing demand for natural compounds due to their efficacy against various microorganisms, and they are being considered as a safer option over synthetic ones. These products or compounds are obtained from different sources including bacteria, plants, animals, etc. All of them exert their action via certain mechanisms derived from their chemical composition and are considered helpful in the control of microorganisms and response to resistance to antibiotics.

The objective of this Special Issue of IJMS is to present the latest research on various aspects of natural antimicrobial products (bio-preservation) as strategies to control pathogenic and spoilage microorganisms. Original research and review articles are invited.

Dr. Jose Javier Sanz-Gómez
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

natural products
chemical composition
spoilage microorganisms
pathogens
food preservatives
biofilms
safety assessment
clean label
antibiotics resistance

Published Papers (3 papers)

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Research

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21 pages, 4662 KiB

Open AccessArticle

Regioselective and Stereoselective Synthesis of Parthenolide Analogs by Acyl Nitroso-Ene Reaction and Their Biological Evaluation against Mycobacterium tuberculosis

by Bruna Gioia, Francesca Ruggieri, Alexandre Biela, Valérie Landry, Pascal Roussel, Catherine Piveteau, Florence Leroux, Ruben C. Hartkoorn and Nicolas Willand

Int. J. Mol. Sci. 2023, 24(24), 17395; https://doi.org/10.3390/ijms242417395 (registering DOI) - 12 Dec 2023

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Abstract

Historically, natural products have played a major role in the development of antibiotics. Their complex chemical structures and high polarity give them advantages in the drug discovery process. In the broad range of natural products, sesquiterpene lactones are interesting compounds because of their diverse biological activities, their high-polarity, and sp³-carbon-rich chemical structures. Parthenolide (PTL) is a natural compound isolated from Tanacetum parthenium, of the family of germacranolide-type sesquiterpene lactones. In recent years, parthenolide has been studied for its anti-inflammatory, antimigraine, and anticancer properties. Recently, PTL has shown antibacterial activities, especially against Gram-positive bacteria. However, few studies are available on the potential antitubercular activities of parthenolide and its analogs. It has been demonstrated that parthenolide’s biological effects are linked to the reactivity of α-exo-methylene-γ-butyrolactone, which reacts with cysteine in targeted proteins via a Michael addition. In this work, we describe the ene reaction of acylnitroso intermediates with parthenolide leading to the regioselective and stereoselective synthesis of new derivatives and their biological evaluation. The addition of hydroxycarbamates and hydroxyureas led to original analogs with higher polarity and solubility than parthenolide. Through this synthetic route, the Michael acceptor motif was preserved and is thus believed to be involved in the selective activity against Mycobacterium tuberculosis. Full article

(This article belongs to the Special Issue Current Research in Antimicrobial Natural Products)

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Review

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40 pages, 12153 KiB

Open AccessReview

Antimicrobial Activity of Arthrospira (Former Spirulina) and Dunaliella Related to Recognized Antimicrobial Bioactive Compounds

by Yana Ilieva, Maya Margaritova Zaharieva, Hristo Najdenski and Alexander Dimitrov Kroumov

Int. J. Mol. Sci. 2024, 25(10), 5548; https://doi.org/10.3390/ijms25105548 - 19 May 2024

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Abstract

With the increasing rate of the antimicrobial resistance phenomenon, natural products gain our attention as potential drug candidates. Apart from being used as nutraceuticals and for biotechnological purposes, microalgae and phytoplankton have well-recognized antimicrobial compounds and proved anti-infectious potential. In this review, we comprehensively outline the antimicrobial activity of one genus of cyanobacteria (Arthrospira, formerly Spirulina) and of eukaryotic microalgae (Dunaliella). Both, especially Arthrospira, are mostly used as nutraceuticals and as a source of antioxidants for health supplements, cancer therapy and cosmetics. Their diverse bioactive compounds provide other bioactivities and potential for various medical applications. Their antibacterial and antifungal activity vary in a broad range and are strain specific. There are strains of Arthrospira platensis with very potent activity and minimum inhibitory concentrations (MICs) as low as 2–15 µg/mL against bacterial fish pathogens including Bacillus and Vibrio spp. Arthrospira sp. has demonstrated an inhibition zone (IZ) of 50 mm against Staphylococcus aureus. Remarkable is the substantial amount of in vivo studies of Arthrospira showing it to be very promising for preventing vibriosis in shrimp and Helicobacter pylori infection and for wound healing. The innovative laser irradiation of the chlorophyll it releases can cause photodynamic destruction of bacteria. Dunaliella salina has exhibited MIC values lower than 300 µg/mL and an IZ value of 25.4 mm on different bacteria, while Dunaliella tertiolecta has demonstrated MIC values of 25 and 50 μg/mL against some Staphylococcus spp. These values fulfill the criteria for significant antimicrobial activity and sometimes are comparable or exceed the activity of the control antibiotics. The bioactive compounds which are responsible for that action are fatty acids including PUFAs, polysaccharides, glycosides, peptides, neophytadiene, etc. Cyanobacteria, such as Arthrospira, also particularly have antimicrobial flavonoids, terpenes, alkaloids, saponins, quinones and some unique-to-them compounds, such as phycobiliproteins, polyhydroxybutyrate, the peptide microcystin, etc. These metabolites can be optimized by using stress factors in a two-step process of fermentation in closed photobioreactors (PBRs). Full article

(This article belongs to the Special Issue Current Research in Antimicrobial Natural Products)

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29 pages, 1249 KiB

Open AccessReview

Multiplicative Effects of Essential Oils and Other Active Components on Skin Tissue and Skin Cancers

by Hyeong Jae Kim and Jeong Hee Hong

Int. J. Mol. Sci. 2024, 25(10), 5397; https://doi.org/10.3390/ijms25105397 - 15 May 2024

Viewed by 346

Abstract

Naturally derived essential oils and their active components are known to possess various properties, ranging from anti-oxidant, anti-inflammatory, anti-bacterial, anti-fungal, and anti-cancer activities. Numerous types of essential oils and active components have been discovered, and their permissive roles have been addressed in various fields. In this comprehensive review, we focused on the roles of essential oils and active components in skin diseases and cancers as discovered over the past three decades. In particular, we opted to highlight the effectiveness of essential oils and their active components in developing strategies against various skin diseases and skin cancers and to describe the effects of the identified essential-oil-derived major components from physiological and pathological perspectives. Overall, this review provides a basis for the development of novel therapies for skin diseases and cancers, especially melanoma. Full article

(This article belongs to the Special Issue Current Research in Antimicrobial Natural Products)

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