Tissue Transglutaminase in Physio-Pathological Conditions
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Neurobiology".
Deadline for manuscript submissions: closed (31 December 2020) | Viewed by 10556
Special Issue Editor
Special Issue Information
Dear Colleagues,
Transglutaminase 2 (TG2) is the most widely distributed and most abundantly expressed member of the transglutaminase family of enzymes, a group of intracellular and extracellular proteins that catalyze the Ca2+-dependent post-translational modification of proteins. It is a unique member of the transglutaminase family owing to its specialized biochemical, structural, and functional elements; ubiquitous tissue distribution and subcellular localization; and substrate specificity. The broad substrate specificity of TG2 and its flexible interaction with numerous other gene products may account for its multiple biological functions. Many such activities have been directly or indirectly implicated in diverse cellular physiological events, including cell growth and differentiation, cell adhesion and morphology, extracellular matrix stabilization, wound healing, cellular development, receptor-mediated endocytosis, apoptosis, and disease pathology. Interestingly, neurodegenerative diseases, such as Alzheimer’s disease, Parkinson’s disease, supranuclear palsy, Huntington’s disease, and other polyglutamine diseases are characterized, in part, by aberrant cerebral transglutaminase activity and by increased crosslinked proteins in affected brains. In this Special Issue we will focus on the possible molecular mechanisms by which these enzymes could be responsible for human diseases and the possible use of transglutaminase inhibitors for patients with diseases characterized by aberrant transglutaminase activity.
Prof. Agata Campisi
Guest Editor
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Keywords
- Transglutaminases
- tissue transglutaminase
- neurodegenerative diseases
- excitotoxicity
- neuroprotection
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