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Special Issue "Thyroid Hormones and NAFLD: New Insights"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (31 July 2020).

Special Issue Editor

Prof. Dr. Giovanni Tarantino
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Guest Editor
Department of Clinical Medicine and Surgery, University of Naples Federico II | UNINA, Naples, Italy
Interests: nonalcoholic fatty liver disease; metabolic syndrome; obesity; atherosclerosis and NAFLD; PCOS and NAFLD; HCV-related chronic hepatitis; HCV-related arthritis; therapy of liver cirrhosis; portal hypertension; hepatic encephalopathy; imaging ultrasonography of liver and spleen; psoriatic arthritis and NAFLD; cytokines in obesity
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Special Issue Information

Dear Colleagues,

Thyroid hormones (TH) control several metabolic activities related to anabolism or catabolism of carbohydrates, proteins, and lipids in order to maintain homeostasis under different physiological conditions. Imbalance of TH levels in the body is associated with multiple chronic diseases, including diabetes mellitus, cardiovascular disease, and liver-related disorders. Recent research provides strong evidence that both overt hypothyroidism and subclinical hypothyroidism are associated, among others, with cardiovascular disease and chronic kidney disease, illnesses often present in patients suffering from advanced forms of NAFLD, the reason many researchers have drawn special attention to the association between TH and NAFLD. Accordingly, a number of observational studies have suggested a strong correlation between hypothyroidism and NAFLD, though there are also studies pointing out that there is no correlation.

Prof. Giovanni Tarantino

Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

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Keywords

  • THS levels
  • Subclinical hypothyroidism
  • Overt hypothyroidism 
  • Independent risk factor 
  • Thyroid function parameters in NAFLD patients 
  • Meta-analyses 
  • Liver cancer 
  • Replacement therapy in NAFLD 
  • Metabolic syndrome 
  • Cytokines levels 
  • ROS and lipid per oxidation

Published Papers (1 paper)

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Review

Open AccessReview
Hypothyroidism-Induced Nonalcoholic Fatty Liver Disease (HIN): Mechanisms and Emerging Therapeutic Options
Int. J. Mol. Sci. 2020, 21(16), 5927; https://doi.org/10.3390/ijms21165927 - 18 Aug 2020
Abstract
Nonalcoholic fatty liver disease (NAFLD) is an emerging worldwide problem and its association with other metabolic pathologies has been one of the main research topics in the last decade. The aim of this review article is to provide an up-to-date correlation between hypothyroidism [...] Read more.
Nonalcoholic fatty liver disease (NAFLD) is an emerging worldwide problem and its association with other metabolic pathologies has been one of the main research topics in the last decade. The aim of this review article is to provide an up-to-date correlation between hypothyroidism and NAFLD. We followed evidence regarding epidemiological impact, immunopathogenesis, thyroid hormone-liver axis, lipid and cholesterol metabolism, insulin resistance, oxidative stress, and inflammation. After evaluating the influence of thyroid hormone imbalance on liver structure and function, the latest studies have focused on developing new therapeutic strategies. Thyroid hormones (THs) along with their metabolites and thyroid hormone receptor β (THR-β) agonist are the main therapeutic targets. Other liver specific analogs and alternative treatments have been tested in the last few years as potential NAFLD therapy. Finally, we concluded that further research is necessary as well as the need for an extensive evaluation of thyroid function in NAFLD/NASH patients, aiming for better management and outcome. Full article
(This article belongs to the Special Issue Thyroid Hormones and NAFLD: New Insights)
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