Search for Articles:
Title / Keyword
Author / Affiliation / Email
Journal
Article Type
 
 
Advanced Search
 
Section
Special Issue
Volume
Issue
Number
Page
 
8.1
4.9
Journals
IJMS
Special Issues
Animal Models for the Study of Human Health and Diseases
ijms-logo
Submit to IJMS Review for IJMS Propose a Special Issue

Journal Menu

► Journal Menu

Journal Browser

► Journal Browser
share announcement

Animal Models for the Study of Human Health and Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (31 January 2025) | Viewed by 383

Special Issue Editor

Prof. Dr. Puliyur S. MohanKumar

E-Mail Website
Guest Editor
Department of Biomedical Sciences, University of Georgia, Athens, GA 30602, USA
Interests: animal model; rats; anatomy; endocrinology; neuroanatomy; neuroendocrinology

Special Issue Information

Dear Colleagues,

Animal models have played a critical role in understanding the pathogenesis and mechanisms of several diseases that are prevalent in animals and humans. They have played a critical role in developing pharmacological interventions that can treat diseases and thereby help in promoting health in animals and humans. Animal models from multiple species can be classified broadly as spontaneous models and models that are induced to imitate the signs and symptoms of diseases. Generally, whether they are spontaneous or developed, they should mimic the pathology and clinical signs of the disease that is being investigated. Although animal models have provided invaluable information related to the pathogenesis and mechanisms of disease, they sometimes fail to recapitulate complex interactions between multiple organ systems and tissues in the body. This results in difficulty comparing them for addressing specific disease conditions. This Special Issue of the International Journal of Molecular Sciences presents various animal models of human diseases of multiple organ systems and their advantages and disadvantages in using them for studying these diseases. This will be an invaluable resource for investigators who are interested in investigating specific diseases using animal models.

Prof. Dr. Puliyur S. MohanKumar
Guest Editor

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • animal models
  • rodents
  • zebrafish
  • drosophila
  • human disease

Benefits of Publishing in a Special Issue

  • Ease of navigation: Grouping papers by topic helps scholars navigate broad scope journals more efficiently.
  • Greater discoverability: Special Issues support the reach and impact of scientific research. Articles in Special Issues are more discoverable and cited more frequently.
  • Expansion of research network: Special Issues facilitate connections among authors, fostering scientific collaborations.
  • External promotion: Articles in Special Issues are often promoted through the journal's social media, increasing their visibility.
  • e-Book format: Special Issues with more than 10 articles can be published as dedicated e-books, ensuring wide and rapid dissemination.

Further information on MDPI's Special Issue policies can be found here.

Published Papers (1 paper)

Order results
Result details
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:

Research

16 pages, 16852 KiB  
Article
Renal Apoptosis in Male Rats Induced by Extensive Dietary Exposure to Ochratoxins
by Peter Mantle, Rohit Upadhyay, Diana Herman and Vecihi Batuman
Int. J. Mol. Sci. 2025, 26(10), 4553; https://doi.org/10.3390/ijms26104553 - 9 May 2025
Viewed by 65
Abstract
During the 70 years since the Balkan endemic nephropathy was recognised, failure to make a universal diagnostic cause continues for some critical researchers. Claims for cause by toxic molecules from microorganisms and/or plants are difficult to verify experimentally in retrospect, partly because no [...] Read more.
During the 70 years since the Balkan endemic nephropathy was recognised, failure to make a universal diagnostic cause continues for some critical researchers. Claims for cause by toxic molecules from microorganisms and/or plants are difficult to verify experimentally in retrospect, partly because no lifetime human experimentation is possible and partly since no experimental source is a convincing model. Apoptosis as a primary step in human nuclear decline has been a source of experiments for many years. Now, one has been used, which employs the detection of abnormal nuclear hydroxyls by using an Abcam histology protocol. Recent access to a few human tissues diagnosed for the Balkan nephropathy has enabled preliminary exploration to publish some positive human manifestations of apoptosis. Parallel use and positive findings have also now illustrated applications to experimental rats’ kidneys after daily dietary exposure to ochratoxin A in lifetime experiments. Focus on renal cortical nephrons and their nuclei reveals a TUNEL-stained pattern with intensity linked to many months of the sub-clinical ochratoxin dietary exposure. The pattern survives long after exposure, but where experimental rats have internally developed cancer did not arise outside the kidney. Our experimental rat findings could not attribute the mechanism for the very different human urothelial tumours to traces of dietary ochratoxin A, but the present study encourages the exploration of more archived Balkan nephropathy renal cases to predict the focal urothelial origin of early tumours. Full article
(This article belongs to the Special Issue Animal Models for the Study of Human Health and Diseases)
Show export options expand_more Show export options expand_less
Select all
Export citation of selected articles as:
 
Displaying articles 1-1
Back to TopTop