Immunophenotyping in Autoimmune Diseases and Cancer, 3rd Edition

Dear Colleagues, 

This Special Issue is the continuation of our Special Issue “Immunophenotyping in Autoimmune Diseases and Cancer” and “Immunophenotyping in Autoimmune Diseases and Cancer 2.0”.

The mammalian immune system is a Janus-faced network of well-coordinated, highly specialized cells and biomolecules. The sensitive balance of reactive and suppressive signals maintains homeostasis in the physiological state. Under pathological conditions, however, responsiveness can escalate in autoimmune diseases or remain suppressed in cancer. In severe autoimmunity, the overwhelming immune response leads to devastating diseases, such as rheumatoid arthritis, systemic lupus erythematosus, systemic sclerosis, sclerosis multiplex, etc. Conversely, immune cells, e.g., professional antigen-presenting cells and cytotoxic T cells, are not able to execute their physiological function in cancer.

Recent progress in fluorescence flow cytometry and mass cytometry has contributed to a high-dimensional resolution of the complex immunophenotype, both in autoimmune diseases and cancer. We request that authors publish their latest achievements associated with the perturbance of the regulation of immune activation and the discovery of rare subpopulations of both innate and adaptive immune players in autoimmune diseases or cancer. This Special Issue will publish works presenting the description of different cellular subtypes and the identification of novel key molecular factors and biomarkers. The submission of mainly research articles is expected. Due to the recent developments in high-content, multilevel profiling technologies, review articles from pioneer scientists will also be considered.

Dr. Gabor J. Szebeni
Dr. Attila Balog
Guest Editors

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