Feature Paper Collection in Molecular Endocrinology and Metabolism
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Editor
Dr. José L. Quiles
Dr. José L. Quiles
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Collection Editor
Department of Physiology, Institute of Nutrition and Food Technology “Jose Mataix”, Biomedical Research Center, University of Granada, Avda. Conocimiento s/n, 18100 Granada, Spain
Interests: cancer biology; antioxidants; oxidative stress; food chemistry; nutrition; reactive oxygen species
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Topical Collection Information
Dear Colleagues,
As Section Editor in Chief of the International Journal of Molecular Sciences, I am very excited to announce the Topical Collection “Feature Paper Collection in Molecular Endocrinology and Metabolism”. The collection aims to collect high-quality research and review articles on all aspects of Endocrinology and Metabolism.
The areas of interest for the Topical Collection embrace, but are not limited to, topics such as:
- Endocrine systems and endocrine-related diseases;
- Molecular, cellular, genetic, epigenetic, developmental approaches, and animal models;
- Novel insights into physiology, pathophysiology, and therapeutics;
- Neuroendocrinology and neuroendocrine control of endocrine axes;
- Classical glands (thyroid, adrenal, pituitary, parathyroid, testis, ovary, pituitary, etc.) and other endocrine systems: gut, bone, liver, etc.;
- Lipids and bone metabolism;
- Hormones, paracrine factors, receptors and binding components, nuclear receptors membrane receptors, and signal transduction pathway;
- Steroid biosynthetic enzymes, metabolism of hormones, neurotransmitters, etc.;
- Cellular interactions and factors involved;
- Energy expenditure;
- Diabetes;
- Infertility and reproductive diseases;
- Obesity;
- Osteoporosis;
- Aging;
- Endocrine-related tumor and cancer;
- Endocrine disruption;
- Crossdisciplinary and integrative studies;
- Comparative aspects of endocrinology.
Dr. José L. Quiles
Collection Editor
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the collection website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript.
There is an Article Processing Charge (APC) for publication in this
open access journal. For details about the APC please see here.
Submitted papers should be well formatted and use good English. Authors may use MDPI's
English editing service prior to publication or during author revisions.
Keywords
- endocrine systems
- endocrine-related diseases
- diabetes
- infertility and reproductive diseases
- obesity
Published Papers (2 papers)
2025
Open AccessArticle
Alkaline Phosphatase as a Potential Biomarker of Muscle Function: A Pilot Study in Patients with Hypophosphatasia
by
María Carmen Andreo-López, Victoria Contreras-Bolívar, Luis Martínez-Heredia, Francisco Andújar-Vera, Diego Becerra-García, Trinidad González-Cejudo, Sheila González-Salvatierra, Cristina García-Fontana, Beatriz García-Fontana and Manuel Muñoz-Torres
Viewed by 75
Abstract
Alkaline phosphatase (ALP) deficiency has been linked to reduced physical performance, as seen in hypophosphatasia (HPP). However, its potential role in muscle function has not been fully explored. This was a cross-sectional study in 34 HPP adults and 34 matched healthy controls. Muscle
[...] Read more.
Alkaline phosphatase (ALP) deficiency has been linked to reduced physical performance, as seen in hypophosphatasia (HPP). However, its potential role in muscle function has not been fully explored. This was a cross-sectional study in 34 HPP adults and 34 matched healthy controls. Muscle strength was assessed using handgrip strength (HGS), considering values below the 10th percentile of the Spanish population as low strength. Muscle mass was evaluated using dual-energy X-ray absorptiometry and morphometric ultrasound. Bone mineral density (BMD) was measured at the lumbar spine, femoral neck, and total hip. The prevalence of low muscle strength was significantly higher in the HPP group compared to controls (30% vs. 6%;
p = 0.009), with decreased HGS in the HPP group (
p = 0.039). Positive associations were observed between ALP and femoral neck BMD, leg circumference, and fat-free mass and an inverse association with tricipital skinfold. Subjects with serum ALP activity below the sex-adjusted median had a significantly higher risk of low muscle strength independently of HPP diagnosis. ALP remained independently associated with HGS (
p = 0.005), and a predictive model using ALP values showed strong capability to predict low-muscle-strength risk. Based on these results, we conclude circulating ALP levels are independently associated with muscle strength and may represent a useful biomarker for the early detection of muscle dysfunction. Future longitudinal or interventional studies are needed to assess whether ALP plays a causal role in muscle strength.
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Open AccessReview
The Perioperative Biochemical and Clinical Considerations of Pheochromocytoma Management
by
Alexa J. Gombert, Alexandra M. Nerantzinis, Jennifer Li, Weidong Wang, Isaac Y. Yeung, Ana Costa and Sergio D. Bergese
Viewed by 169
Abstract
Pheochromocytoma, a rare catecholamine-secreting tumor, poses significant perioperative challenges due to its potential for severe hemodynamic instability. Careful management of patients with pheochromocytoma is critical for patient safety and favorable outcomes. The diagnostic workup focuses on biochemical analysis of plasma or urinary metanephrines,
[...] Read more.
Pheochromocytoma, a rare catecholamine-secreting tumor, poses significant perioperative challenges due to its potential for severe hemodynamic instability. Careful management of patients with pheochromocytoma is critical for patient safety and favorable outcomes. The diagnostic workup focuses on biochemical analysis of plasma or urinary metanephrines, followed by imaging for tumor localization and genetic testing to identify hereditary syndromes. Preoperative management emphasizes adequate alpha-adrenergic blockade followed by beta-blockade to stabilize cardiovascular function. Anesthetic planning requires meticulous attention to volume status, cardiovascular optimization, and intraoperative monitoring to mitigate the risks of hypertensive crises and hypotension. Postoperative care must account for ongoing hemodynamic and metabolic fluctuations. A multidisciplinary, protocol-driven approach is essential to improve outcomes in patients undergoing pheochromocytoma resection. This paper provides a comprehensive overview of the genetic, biochemical, clinical, and anesthetic considerations involved in the diagnosis and perioperative management of pheochromocytoma.
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