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Obstructive Sleep Apnea and Inflammation: Proof of Concept Based on Two Illustrative Cytokines

Child Health Research Institute, Department of Child Health, University of Missouri School of Medicine, Columbia, MO 65201, USA
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(3), 459;
Received: 21 December 2018 / Revised: 12 January 2019 / Accepted: 15 January 2019 / Published: 22 January 2019
(This article belongs to the Special Issue Sleep Apnea and Intermittent Hypoxia)
PDF [521 KB, uploaded 22 January 2019]


Obstructive sleep apnea syndrome (OSAS) is a markedly prevalent condition across the lifespan, particularly in overweight and obese individuals, which has been associated with an independent risk for neurocognitive, behavioral, and mood problems as well as cardiovascular and metabolic morbidities, ultimately fostering increases in overall mortality rates. In adult patients, excessive daytime sleepiness (EDS) is the most frequent symptom leading to clinical referral for evaluation and treatment, but classic EDS features are less likely to be reported in children, particularly among those with normal body-mass index. The cumulative evidence collected over the last two decades supports a conceptual framework, whereby sleep-disordered breathing in general and more particularly OSAS should be viewed as low-grade chronic inflammatory diseases. Accordingly, it is assumed that a proportion of the morbid phenotypic signature in OSAS is causally explained by underlying inflammatory processes inducing end-organ dysfunction. Here, the published links between OSAS and systemic inflammation will be critically reviewed, with special focus on the pro-inflammatory cytokines tumor necrosis factor α (TNF-α) and interleukin 6 (IL-6), since these constitute classical prototypes of the large spectrum of inflammatory molecules that have been explored in OSAS patients. View Full-Text
Keywords: sleep apnea; inflammation; cytokines; excessive daytime sleepiness; sleep sleep apnea; inflammation; cytokines; excessive daytime sleepiness; sleep

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Kheirandish-Gozal, L.; Gozal, D. Obstructive Sleep Apnea and Inflammation: Proof of Concept Based on Two Illustrative Cytokines. Int. J. Mol. Sci. 2019, 20, 459.

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