Journal Menu► ▼ Journal Menu
Journal Browser► ▼ Journal Browser
Special Issue "Sirtuins in Health and Disease"
Deadline for manuscript submissions: 30 June 2020.
Interests: cardiovascular disease; heart failure; diabetes; cardiac energy metabolism
The discovery and characterization of sirtuins as NAD+-dependent deacylases have revolutionized our understanding of post-translational protein regulation. In fact, numerous post-translational modifications have been attributed to the activity of different sirtuins with distinct cellular localization, and recent findings have advanced our knowledge of the importance of sirtuin-catalyzed posttranslational modifications in health and disease. Sirtuins have been identified as major regulators of a variety of fundamental intracellular pathways and, thus, play a critical role in aging, energy metabolism, and in the adaptation to cellular stressors. That said, sirtuins have been implicated in the pathology of age-related maladies, including cancer, diabetes, and neurodegenerative or cardiovascular diseases, mostly mediating protective effects upon activation. Of note, clinical trials have been initiated to evaluate the therapeutic potential of sirtuin activation.
This Special Issue in the International Journal of Molecular Sciences aims at presenting contemporary research on the role of sirtuins both in health and disease, which shall include research in different organisms and models, and can spread across the entirety of cellular physiology and organ disease. We cordially invite you to submit original articles, review articles, methodological papers, as well as studies related to clinical cases. We encourage researchers to address the current knowledge as well as existing controversies, or present outstanding questions and new concepts related to sirtuins and NAD+ metabolism.
Dr. Heiko Bugger
Dr. Simon Sedej
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Caloric restriction
- NAD+ metabolism
- Metabolic disease
- Posttranslational modification