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Special Issue "Sirtuins in Health and Disease"

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".

Deadline for manuscript submissions: 30 June 2020.

Special Issue Editors

Dr. Heiko Bugger
E-Mail Website
Guest Editor
Division of Cardiology, Medical University of Graz, Graz, Austria
Interests: cardiovascular disease; heart failure; diabetes; cardiac energy metabolism
Dr. Simon Sedej
E-Mail Website
Guest Editor
1. Division of Cardiology, Medical University of Graz, Graz, Austria
2. BioTechMed Graz, Graz, Austria
Interests: caloric restriction mimetics; autophagy; myocardial remodeling, heart failure; aging; metabolic syndrome

Special Issue Information

Dear Colleagues,

The discovery and characterization of sirtuins as NAD+-dependent deacylases have revolutionized our understanding of post-translational protein regulation. In fact, numerous post-translational modifications have been attributed to the activity of different sirtuins with distinct cellular localization, and recent findings have advanced our knowledge of the importance of sirtuin-catalyzed posttranslational modifications in health and disease. Sirtuins have been identified as major regulators of a variety of fundamental intracellular pathways and, thus, play a critical role in aging, energy metabolism, and in the adaptation to cellular stressors. That said, sirtuins have been implicated in the pathology of age-related maladies, including cancer, diabetes, and neurodegenerative or cardiovascular diseases, mostly mediating protective effects upon activation. Of note, clinical trials have been initiated to evaluate the therapeutic potential of sirtuin activation.

This Special Issue in the International Journal of Molecular Sciences aims at presenting contemporary research on the role of sirtuins both in health and disease, which shall include research in different organisms and models, and can spread across the entirety of cellular physiology and organ disease. We cordially invite you to submit original articles, review articles, methodological papers, as well as studies related to clinical cases. We encourage researchers to address the current knowledge as well as existing controversies, or present outstanding questions and new concepts related to sirtuins and NAD+ metabolism.

Dr. Heiko Bugger
Dr. Simon Sedej
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • Caloric restriction
  • Aging
  • NAD+ metabolism
  • Sirtuin
  • Acetylation
  • Metabolic disease
  • Longevity
  • Posttranslational modification

Published Papers (1 paper)

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Review

Open AccessReview
Sirtuins and SIRT6 in Carcinogenesis and in Diet
Int. J. Mol. Sci. 2019, 20(19), 4945; https://doi.org/10.3390/ijms20194945 - 07 Oct 2019
Abstract
Sirtuins are a highly conserved family of nicotinamide adenine dinucleotide (NAD)-dependent protein lysine modifying enzymes. They are key regulators for a wide variety of cellular and physiological processes such as cell proliferation, differentiation, DNA damage and stress response, genome stability, cell survival, metabolism, [...] Read more.
Sirtuins are a highly conserved family of nicotinamide adenine dinucleotide (NAD)-dependent protein lysine modifying enzymes. They are key regulators for a wide variety of cellular and physiological processes such as cell proliferation, differentiation, DNA damage and stress response, genome stability, cell survival, metabolism, energy homeostasis, organ development and aging. Aging is one of the major risk factors of cancer, as many of the physiological mechanisms and pathologies associated with the aging process also contribute to tumor initiation, growth and/or metastasis. This review focuses on one the mammalian sirtuins, SIRT6, which has emerged as an important regulator of longevity and appears to have multiple biochemical functions that interfere with tumor development and may be useful in cancer prevention and for site-specific treatment. The recent evidence of the role of SIRT6 in carcinogenesis is also discussed, focusing on the potential use of SIRT6 modulators in cancer nanomedicine. Full article
(This article belongs to the Special Issue Sirtuins in Health and Disease)
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