A Molecular Perspective on Sirtuin Activity
Abstract
:1. Introduction
2. Protein Acylation
2.1. N-Terminal Acylation
N-Terminal Acetylation
2.2. Acylation of Internal Lysine Residues
Acetylation of Internal Lysine Residues
2.3. S-Palmitoylation of Cysteine Residues
2.4. The Influence of Protein Acylation in Human Health and Disease
Protein Acylation and “Carbon Stress”
3. Protein Deacylation
3.1. Zn2+-Dependent KDACs
3.2. NAD+-Dependent Sirtuin Deacetylases
3.2.1. Sirtuin Structure
3.2.2. Substrate Specificity of Sirtuins
The Influence of Sirtuin Structure
The Influence of the Subcellular Localization of Sirtuins
The Influence of the Acylated Residue
The Influence of the Acyl Group
The Influence of Protein Structure
The Influence of Protein Sequence
The Influence of Protein Interactions
3.2.3. Catalytic Mechanism of Sirtuin Deacylation
3.2.4. The Influence of Sirtuins in Human Health and Disease
4. Conclusions
Author Contributions
Funding
Conflicts of Interest
References
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Teixeira, C.S.S.; Cerqueira, N.M.F.S.A.; Gomes, P.; Sousa, S.F. A Molecular Perspective on Sirtuin Activity. Int. J. Mol. Sci. 2020, 21, 8609. https://doi.org/10.3390/ijms21228609
Teixeira CSS, Cerqueira NMFSA, Gomes P, Sousa SF. A Molecular Perspective on Sirtuin Activity. International Journal of Molecular Sciences. 2020; 21(22):8609. https://doi.org/10.3390/ijms21228609
Chicago/Turabian StyleTeixeira, Carla S. S., Nuno M. F. S. A. Cerqueira, Pedro Gomes, and Sérgio F. Sousa. 2020. "A Molecular Perspective on Sirtuin Activity" International Journal of Molecular Sciences 21, no. 22: 8609. https://doi.org/10.3390/ijms21228609
APA StyleTeixeira, C. S. S., Cerqueira, N. M. F. S. A., Gomes, P., & Sousa, S. F. (2020). A Molecular Perspective on Sirtuin Activity. International Journal of Molecular Sciences, 21(22), 8609. https://doi.org/10.3390/ijms21228609