Signal Transduction Pathways Regulated by Vascular Endothelial Growth Factor
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 March 2021) | Viewed by 14233
Special Issue Editor
2. Department of Neurology, Miller School of Medicine, University of Miami, Miami, FL 33136, USA
Interests: vascular disease; aging; genetics; neurology; epidemiology; basic science; oxidative stress; stroke; atherosclerosis; ischemic preconditioning; diabetes; sarcopenia; nutrition
Special Issue Information
Dear Colleagues,
In the last few decades, among the most controversial and debated transduction signals associated with chronic diseases, such as cancer, cardiovascular disease, neurological disorders, and eye diseases among others, there is the signal transduction regulated by the Vascular Endothelial Growth Factor (VEGF). Since its discovery, VEGF has revolutionized our consideration on all processes of vasculogenesis and angiogenesis during physiological vascular homeostasis underlying tissue growth. VEGF, also known as VEGF-A, is the most well characterized member of the cysteine-knot growth factors family. Hypoxia is a major regulator of VEGF expression via hypoxia inducible factor (HIF). Then, when activated, VEGF displays several activities such as pro-angiogenic function, vascular permeability, and vasodilation. However, as largely demonstrated, these VEGF properties lead to the formation of new blood vessels, which may be structurally abnormal in the case of tumors. Moreover, alternative exon splicing on the vegf gene leads to multiple VEGF isoforms with different pro-angiogenic activities, as well as different single nucleotide polymorphisms (SNPs) in the same gene, which have been associated with a significant variability in the association with chronic diseases in humans. Therapies targeting VEGF and its signal transduction are currently available and research in this field is ongoing. However, it is imperative to understand the complex interactions between VEGF and other signaling pathways regulating the same vascular/tissue processes in order to clearly define the beyond rational and insight of targeting VEGF against chronic diseases. With this aim, original contributions, comprehensive reviews, or perspective articles are more than welcome for this Special Issue.
Prof. Dr. David Della-Morte
Guest Editor
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Keywords
- Vascular endothelial growth factor
- Cardiovascular diseases
- Cancer
- Eye diseases
- Neurological diseases
- Angiogenesis
- Genetics
- Epigenetics
- Hypoxia
- Anti-VEGF therapy
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