Special Issue "SAR "Out of the Box": From Pharmacological Drug Design to Cellular Activity of Biomolecules from Plants and Bacteria to Animals"
Deadline for manuscript submissions: closed (26 May 2019).
Interests: molecular modelling, protein sequence analysis, protein and peptide–lipid interaction, membrane interaction, structure–activity reationships (SAR), molecular biophysics
Special Issues and Collections in MDPI journals
Interests: amphiphilic molecules, biomimetic membranes, membrane interactions, in vitro molecular biophysics, molecular mechanisms, structure–activity relationships, lipid specificity
Classically, the structure–activity relationship (SAR) is an approach designed to find relationships between the chemical structure (or structural-related properties), 3D structure, and biological activity of studied compounds, as defined by Crum-Brown and Fraser in 1865. This is because similar compounds should have similar physico-chemical and biological properties. If this notion is almost always associated with pharmacological drug design and the assessment of side effects of existing compounds in the human health field, it can actually be extended to a large number of bioactive molecules exerting a number of cellular activities. For instance, interactions between plant or bacterial secondary metabolites as well as proteins belonging to the same structural family could have differential activities at the level of the cellular membrane. This Special Issue is dedicated to widening the notion of SAR to a more general concept concerning the relationships between structure and activity of bioactive molecules belonging to all living organisms, whether they have pharmacological effects or not.
Prof. Dr. Laurence Lins
Dr. Magali Deleu
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- membrane activity of biomolecules
- synthesis/hemisynthesis of bioactive molecules
- chemical characterization of biomolecules related to their activity
- protein structure–activity relationships
- secondary metabolite structure–biological activity relationships
- drug design