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Review

Is It Possible to Predict the Odor of a Molecule on the Basis of its Structure?

1
Laboratory of Chemistry of Natural Molecules, Gembloux Agro-Bio Tech, University of Liège, 5030 Gembloux, Belgium
2
Laboratory of Molecular Biophysics at Interfaces, Gembloux Agro-Bio Tech, University of Liège, 5030 Gembloux, Belgium
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(12), 3018; https://doi.org/10.3390/ijms20123018
Received: 29 May 2019 / Revised: 17 June 2019 / Accepted: 18 June 2019 / Published: 20 June 2019
The olfactory sense is the dominant sensory perception for many animals. When Richard Axel and Linda B. Buck received the Nobel Prize in 2004 for discovering the G protein-coupled receptors’ role in olfactory cells, they highlighted the importance of olfaction to the scientific community. Several theories have tried to explain how cells are able to distinguish such a wide variety of odorant molecules in a complex context in which enantiomers can result in completely different perceptions and structurally different molecules. Moreover, sex, age, cultural origin, and individual differences contribute to odor perception variations that complicate the picture. In this article, recent advances in olfaction theory are presented, and future trends in human olfaction such as structure-based odor prediction and artificial sniffing are discussed at the frontiers of chemistry, physiology, neurobiology, and machine learning. View Full-Text
Keywords: olfaction; odor; sensory perception; flavor; volatile organic compounds; structure-function relationship; olfactory sense; odorant olfaction; odor; sensory perception; flavor; volatile organic compounds; structure-function relationship; olfactory sense; odorant
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MDPI and ACS Style

Genva, M.; Kenne Kemene, T.; Deleu, M.; Lins, L.; Fauconnier, M.-L. Is It Possible to Predict the Odor of a Molecule on the Basis of its Structure? Int. J. Mol. Sci. 2019, 20, 3018. https://doi.org/10.3390/ijms20123018

AMA Style

Genva M, Kenne Kemene T, Deleu M, Lins L, Fauconnier M-L. Is It Possible to Predict the Odor of a Molecule on the Basis of its Structure? International Journal of Molecular Sciences. 2019; 20(12):3018. https://doi.org/10.3390/ijms20123018

Chicago/Turabian Style

Genva, Manon, Tierry Kenne Kemene, Magali Deleu, Laurence Lins, and Marie-Laure Fauconnier. 2019. "Is It Possible to Predict the Odor of a Molecule on the Basis of its Structure?" International Journal of Molecular Sciences 20, no. 12: 3018. https://doi.org/10.3390/ijms20123018

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