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Special Issue "Molecular Research on Rett Syndrome and Related Disorders: From the Past Towards the Future"
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (31 July 2019).
2. IRCCS San Raffaele Hospital/Division of Neuroscience, Milan, Italy
Interests: Rett syndrome; MeCP2; CDKL5; epigenetics; neurodevelopment
Dramatic progress has been made since the MECP2 gene was discovered as the main cause of Rett syndrome, providing geneticists with molecular diagnostic tools and researchers with a plethora of animal models and molecular pathways that might be relevant for treatments. Importantly, several laboratories have been able to demonstrate that Rett syndrome, and possibly related disorders, are not irreversible conditions, at least in mice. This has boosted research on the pathophysiology of these diseases, the biological roles of the involved genes, and the identification of the affected molecular pathways.
Despite this enormous acceleration of research in Rett syndrome and related disorders, no cure is still available. The identification of valid therapeutic approaches will certainly benefit from the development of new basic and pre-clinical studies based on a critical analysis of past molecular research.
Considering all of the above, we would like to invite original articles or reviews that focus on genes involved in Rett syndrome and related disorders, including MECP2, CDKL5, and FOXG1, and highlight deregulated molecular mechanisms, their potential involvement in the pathophysiology, and their therapeutic value.
Prof. Dr. Nicoletta Landsberger
Dr. Angelisa Frasca
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
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- MECP2 and its molecular roles
- CDKL5 and its molecular roles
- FOXG1 and its molecular roles
- Novel genes associated with Rett syndrome and related disorders
- Molecular dysfunctions in Rett syndrome and related disorders
- Therapeutic approaches for Rett syndrome and related disorders