Special Issue "RNA Regulatory Networks"
Deadline for manuscript submissions: 31 December 2019
Prof. Dr. John Mattick
Green Templeton College, University of Oxford, Oxford, United Kingdom
Website | E-Mail
Interests: non-coding RNA biology; RNA structure-function relationships; development; epigenetic regulation; neurological diseases; cardiovascular diseases; cancer; infectious diseases; cell organization; cell-to-cell communication; circulating RNAs; biomarkers
Dear Colleagues,The centrality of RNA in the flow of information from the genome is the basis of the classical dogma of cell biology. However, the rules and roles governing RNA functions have been dramatically expanded during the last two decades with the discovery of the pervasive transcription of eukaryotic genomes and the growing appreciation of non-coding RNA as a plastic and versatile molecule that carries out a myriad of functions ranging from enzymatic catalysis to scaffolding of protein complexes, nucleation of subcellular domains, and the dynamic organization of chromatin.
The fact that noncoding RNAs (ncRNAs) are prevalent in the transcriptomes of humans and other complex organisms suggests that a second tier of genetic output has evolved in these organisms, to enable the integration and coordination of sophisticated suites of gene expression required for differentiation and development, and that may be perturbed in cancer and neurological disorders, among others. Moreover, the expansion of the complement of ncRNAs in the higher organisms suggests that the evolution of complexity may not have been simply dependent on an expanded repertoire of proteins and protein isoforms but on a (much) larger set of genomic design instructions embedded in trans-acting RNAs, which drive the epigenetic trajectories of development and can respond to internal and external cues through RNA editing and modification.
This Special Issue will welcome scientific contributions and critical reviews analyzing the role and biological functions of RNA-centred regulatory networks in the context of development, brain function, cell physiology, and human disease. We will also collect papers from The 3rd International Symposium on Frontiers in Molecular Science—RNA Regulatory Networks (ISFMS 2019), organized by Universidade de Lisboa, which will be held in Lisbon (Portugal) from 26–28th June 2019. This meeting will analyze the centrality of RNA regulation in biological processes and human disease, and will constitute an excellent opportunity for the interchange of ideas and the presentation of new scientific developments in the field. It will consider the many dimensions of RNA regulation in development and disease, RNA structure-function relationships, the mechanisms by which plasticity is introduced, and the role of RNA in transgenerational communication.
Prof. Dr. Francisco J. Enguita
Prof. Dr. John Mattick
Manuscript Submission Information
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- RNA-based regulation
- non-coding RNAs
- RNA editing
- cell-to-cell communication
- metabolic disease
- RNA structure
- Genome dynamics
- RNA structure-function relationships
- Methods for functional RNA studies