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Review

Interspecies Communication in Holobionts by Non-Coding RNA Exchange

1
Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Campus da Caparica, 2829-516 Caparica, Portugal
2
MEtRICs, Faculdade de Ciências e Tecnologia, Universidade Nova de Lisboa, Campus da Caparica, 2829-516 Caparica, Portugal
3
Instituto de Medicina Molecular João Lobo Antunes, Faculdade de Medicina, Universidade de Lisboa, Av. Prof. Egas Moniz, 1649-028 Lisboa, Portugal
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(7), 2333; https://doi.org/10.3390/ijms21072333
Received: 30 December 2019 / Revised: 24 March 2020 / Accepted: 26 March 2020 / Published: 27 March 2020
(This article belongs to the Special Issue RNA Regulatory Networks)
Complex organisms are associations of different cells that coexist and collaborate creating a living consortium, the holobiont. The relationships between the holobiont members are essential for proper homeostasis of the organisms, and they are founded on the establishment of complex inter-connections between all the cells. Non-coding RNAs are regulatory molecules that can also act as communication signals between cells, being involved in either homeostasis or dysbiosis of the holobionts. Eukaryotic and prokaryotic cells can transmit signals via non-coding RNAs while using specific extracellular conveyors that travel to the target cell and can be translated into a regulatory response by dedicated molecular machinery. Within holobionts, non-coding RNA regulatory signaling is involved in symbiotic and pathogenic relationships among the cells. This review analyzes current knowledge regarding the role of non-coding RNAs in cell-to-cell communication, with a special focus on the signaling between cells in multi-organism consortia. View Full-Text
Keywords: non-coding RNA; inter-kingdom communication; microbiome; holobiont; hologenome; extracellular ncRNAs; miRNAs; metagenome; metatranscriptome non-coding RNA; inter-kingdom communication; microbiome; holobiont; hologenome; extracellular ncRNAs; miRNAs; metagenome; metatranscriptome
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MDPI and ACS Style

Leitão, A.L.; Costa, M.C.; Gabriel, A.F.; Enguita, F.J. Interspecies Communication in Holobionts by Non-Coding RNA Exchange. Int. J. Mol. Sci. 2020, 21, 2333. https://doi.org/10.3390/ijms21072333

AMA Style

Leitão AL, Costa MC, Gabriel AF, Enguita FJ. Interspecies Communication in Holobionts by Non-Coding RNA Exchange. International Journal of Molecular Sciences. 2020; 21(7):2333. https://doi.org/10.3390/ijms21072333

Chicago/Turabian Style

Leitão, Ana L., Marina C. Costa, André F. Gabriel, and Francisco J. Enguita 2020. "Interspecies Communication in Holobionts by Non-Coding RNA Exchange" International Journal of Molecular Sciences 21, no. 7: 2333. https://doi.org/10.3390/ijms21072333

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