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Advances in the Pharmacological Treatment of Dementia

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: closed (31 July 2023) | Viewed by 5007

Special Issue Editor


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Guest Editor
Department of Neurology, Taipei Medical University Shuang-Ho Hospital, New Taipei City 235041, Taiwan
Interests: dementia; pharmacological treatment; preclinical; disease modifying

Special Issue Information

Dear Colleagues,

The causes of dementia are diverse, and symptomatic or disease-modifying treatment of dementia both have unmet medical needs. Many novel treatments for dementia including small molecules, antibodies, and cell therapy are being developed. These treatments usually target the underlying pathophysiological mechanisms, such as neuroprotection, anti-neuroinflammation, toxic protein removal, neuro-regeneration, etc. This Special Issue will focus on the basic preclinical studies or clinical trials in early stages about the treatment of any kind of dementia, especially the pharmacological approaches.  Both original reports and review articles are welcome. To align with the scope of this journal, exploration of the molecular mechanisms or related evidence/information are requested. 

We hope to provide a condensed and comprehensive picture of advances in the treatment of dementia in this Special Issue.

Prof. Dr. Chaur-Jong Hu
Guest Editor

Manuscript Submission Information

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Keywords

  • dementia
  • pharmacological treatment
  • preclinical
  • disease modifying

Published Papers (1 paper)

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Review

17 pages, 1708 KiB  
Review
Clinical Trials of New Drugs for Vascular Cognitive Impairment and Vascular Dementia
by Tran Thanh Duy Linh, Yi-Chen Hsieh, Li-Kai Huang and Chaur-Jong Hu
Int. J. Mol. Sci. 2022, 23(19), 11067; https://doi.org/10.3390/ijms231911067 - 21 Sep 2022
Cited by 8 | Viewed by 4344
Abstract
Population aging has challenged the treatment of cognitive impairment or dementia. Vascular dementia is the second leading cause of dementia after Alzheimer’s disease. Cognitive consequences after ischemic brain injury have been recognized as a preferred target for therapeutic strategies, prompting the search for [...] Read more.
Population aging has challenged the treatment of cognitive impairment or dementia. Vascular dementia is the second leading cause of dementia after Alzheimer’s disease. Cognitive consequences after ischemic brain injury have been recognized as a preferred target for therapeutic strategies, prompting the search for potential agents. The keyword “vascular dementia” was used to search ClinicalTrials.gov to determine agents represented in phases I, II, III, and IV. The agents were classified on the basis of their mechanisms. Of the 17 randomized controlled trials meeting our inclusion criteria, 9 were completed in the past 10 years, and 8 are ongoing or in the planning stages. We also identified one trial in phase I, nine in phase II, six in phase III, and one in phase IV. Fewer trials of new drugs for improving cognition or ameliorating the behavioral and psychological symptoms of dementia target vascular dementia than Alzheimer’s dementia. Drug trials on vascular dementia overlap with drug trials targeting functional outcomes in cerebrovascular disease. International pharmaceutical companies’ investment in new drugs targeting VCI and vascular dementia remains insufficient. Full article
(This article belongs to the Special Issue Advances in the Pharmacological Treatment of Dementia)
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