β-Cell Maturation and Identity in Health and Disease
Abstract
:1. Introduction
2. Embryonic Development: Rise of β-Cells
3. Postnatal Development: Road to Maturity
3.1. Markers
3.2. Functionality
3.3. Signaling Pathways
4. Diabetic Conditions: β-Cells Derail
4.1. Dedifferentiated β-Cells
4.2. Polyhormonal Cells and Endcorine Cell Transdifferentiation
4.3. Senescence
5. β-Cell Differentiation Protocols: How to Make “Real” β-Cells
6. Concluding Remarks
Author Contributions
Acknowledgments
Conflicts of Interest
References
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Salinno, C.; Cota, P.; Bastidas-Ponce, A.; Tarquis-Medina, M.; Lickert, H.; Bakhti, M. β-Cell Maturation and Identity in Health and Disease. Int. J. Mol. Sci. 2019, 20, 5417. https://doi.org/10.3390/ijms20215417
Salinno C, Cota P, Bastidas-Ponce A, Tarquis-Medina M, Lickert H, Bakhti M. β-Cell Maturation and Identity in Health and Disease. International Journal of Molecular Sciences. 2019; 20(21):5417. https://doi.org/10.3390/ijms20215417
Chicago/Turabian StyleSalinno, Ciro, Perla Cota, Aimée Bastidas-Ponce, Marta Tarquis-Medina, Heiko Lickert, and Mostafa Bakhti. 2019. "β-Cell Maturation and Identity in Health and Disease" International Journal of Molecular Sciences 20, no. 21: 5417. https://doi.org/10.3390/ijms20215417