Next Article in Journal
Novel Mutations Segregating with Complete Androgen Insensitivity Syndrome and Their Molecular Characteristics
Next Article in Special Issue
Stratifying Intraductal Papillary Mucinous Neoplasms by Cyst Fluid Analysis: Present and Future
Previous Article in Journal
PFKFB3 Inhibition Attenuates Oxaliplatin-Induced Autophagy and Enhances Its Cytotoxicity in Colon Cancer Cells
Previous Article in Special Issue
Wnt/β-Catenin Signaling: The Culprit in Pancreatic Carcinogenesis and Therapeutic Resistance
Open AccessReview

β-Cell Maturation and Identity in Health and Disease

by Ciro Salinno 1,2,3,4, Perla Cota 1,2,3,4, Aimée Bastidas-Ponce 1,2,3,4, Marta Tarquis-Medina 1,2,3,4, Heiko Lickert 1,2,3,4,* and Mostafa Bakhti 1,2,3,*
1
Institute of Diabetes and Regeneration Research, Helmholtz Zentrum München, D-85764 Neuherberg, Germany
2
German Center for Diabetes Research (DZD), D-85764 Neuherberg, Germany
3
Institute of Stem Cell Research, Helmholtz Zentrum München, D-85764 Neuherberg, Germany
4
School of Medicine, Technical University of Munich, 81675Munich, Germany
*
Authors to whom correspondence should be addressed.
Int. J. Mol. Sci. 2019, 20(21), 5417; https://doi.org/10.3390/ijms20215417
Received: 9 October 2019 / Revised: 28 October 2019 / Accepted: 28 October 2019 / Published: 30 October 2019
(This article belongs to the Special Issue Cell and Molecular Biology of Pancreatic Disorders 2019)
The exponential increase of patients with diabetes mellitus urges for novel therapeutic strategies to reduce the socioeconomic burden of this disease. The loss or dysfunction of insulin-producing β-cells, in patients with type 1 and type 2 diabetes respectively, put these cells at the center of the disease initiation and progression. Therefore, major efforts have been taken to restore the β-cell mass by cell-replacement or regeneration approaches. Implementing novel therapies requires deciphering the developmental mechanisms that generate β-cells and determine the acquisition of their physiological phenotype. In this review, we summarize the current understanding of the mechanisms that coordinate the postnatal maturation of β-cells and define their functional identity. Furthermore, we discuss different routes by which β-cells lose their features and functionality in type 1 and 2 diabetic conditions. We then focus on potential mechanisms to restore the functionality of those β-cell populations that have lost their functional phenotype. Finally, we discuss the recent progress and remaining challenges facing the generation of functional mature β-cells from stem cells for cell-replacement therapy for diabetes treatment. View Full-Text
Keywords: β-cell; maturation; postnatal; identity; dysfunction; dedifferentiation; transdifferentiation; senescence; SC-β-cells; diabetes β-cell; maturation; postnatal; identity; dysfunction; dedifferentiation; transdifferentiation; senescence; SC-β-cells; diabetes
Show Figures

Figure 1

MDPI and ACS Style

Salinno, C.; Cota, P.; Bastidas-Ponce, A.; Tarquis-Medina, M.; Lickert, H.; Bakhti, M. β-Cell Maturation and Identity in Health and Disease. Int. J. Mol. Sci. 2019, 20, 5417.

Show more citation formats Show less citations formats
Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Article Access Map by Country/Region

1
Back to TopTop