Molecular Mechanisms and Therapeutics of Parkinson's Disease 2022
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".
Deadline for manuscript submissions: closed (18 August 2023) | Viewed by 15255
Special Issue Editor
Special Issue Information
Dear Colleagues,
Parkinson's Disease (PD) is characterized by the progressive degeneration of dopaminergic neurons (DA-neurons) and the gradual depletion of dopamine (DA). Current treatments replenish the DA deficit and improve symptoms, but neurodegeneration continues. Neuroprotection treatments do not affect patient symptoms but aim to modulate remarkably diverse pathways and, despite intense efforts, neuroprotective therapies have not been discovered.
Deciphering the molecular mechanisms of PD pathogenesis is of paramount importance in stopping neurodegeneration. Experimental evidence and postmortem studies support the involvement of protein toxicity, mitochondrial dysfunction, and oxidative stress, as well as glial cell mediated neuroinflammation.
Even though the etiology of PD for the vast majority of cases remains unknown, genetics and association studies have revealed more than twenty loci and several environmental factors to be implicated. These discoveries have created a resurgence of research offering deeper understanding of the pathogenetic pathways and provide potential targets for novel treatments. Indeed, several new approaches are currently undergoing clinical trials, raising expectations for a cure.
This Special Issue aims to collect exciting new findings on the molecular mechanisms of PD pathogenesis, as well as on translational research of PD therapeutics. We cordially invite authors to contribute original research articles focusing on molecular, cellular, or whole organism experimental evidence helping to validate mechanisms for neuroprotection. Such experimental evidence could include, but it is not limited to:
- The molecular role of genetically, or otherwise, identified factors in protein toxicity, mitochondrial dysfunction, and oxidative stress, as well as glial cell mediated neuroinflammation related to PD.
- Mechanistic insights of altered expression levels due to neuroprotective or neurodegenerative interventions in preclinical models.
- Biochemical or expression level adaptations during aging that predispose or protect from PD.
- Molecular mechanisms leading to neuronal survival.
- Mechanism of action of Pharmacological agents for PD.
- Molecular or genetic manipulation (overexpression / knockdown) affecting neuroprotective or neurodegenerative outcome.
Dr. Demetrios K. Vassilatis
Guest Editor
Manuscript Submission Information
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Keywords
- Parkinson’s disease
- neuroprotection
- neurodegeneration
- tatget validation
- drug discovery
- drug mode of action
- neuroinflammation
- molecular medicine
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