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Recent Perspectives on Oxidative Stress, Metabolic and Inflammatory Diseases

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Pathology, Diagnostics, and Therapeutics".

Deadline for manuscript submissions: 20 June 2024 | Viewed by 1428

Special Issue Editors


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Guest Editor
Department of Morphology, Surgery & Experimental Medicine, University of Ferrara, 44121 Ferrara, Italy
Interests: autoinflammatory diseases; periodic fever; mevalonate kinase deficiency; mitochondria; neuronal dysfunction
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Guest Editor
1. Department of Morphology, Surgery & Experimental Medicine, University of Ferrara, 44121 Ferrara, Italy
2. LTTA Centre, University of Ferrara, 44121 Ferrara, Italy
Interests: role of TRAIL and OPG systems in osteoclastic differentiation and cancer; apoptotic effects evaluation of different drugs in chronic lymphocytic leukemia models; circulating cytokines/chemokines assessment; morphological studies; transmission electron microscopy and immunohistochemistry
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

The studies on the pathogenesis of various inflammatory and metabolic diseases in adults and children have evidenced a strong link among oxidative stress and inflammation. Mitochondria are the hub of cell redox homeostasis, since they are fundamental in ROS production and also serve as ROS targets. As a consequence, their dysfunction is involved in different aspects of the inflammatory process.

This Special Issue is aimed at providing the reader with the most recent advances in the field, focusing on studies that evaluate novel aspects about the complex cellular and molecular mechanisms underlying metabolic and inflammatory diseases and the strategies for the identification of effective and innovative pharmacological treatments.

Physicians, immunologists, biologists and pharmacologists are invited to contribute to this Special Issue by submitting papers that may be in the form of original studies, reviews, case studies and meta-analyses on this topic.

Prof. Dr. Annalisa Marcuzzi
Dr. Erika Rimondi
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

 

Keywords

  • inflammation
  • oxidative stress
  • cytokines
  • mitochondria metabolic diseases

Published Papers (1 paper)

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Review

27 pages, 1857 KiB  
Review
Classical and Innovative Evidence for Therapeutic Strategies in Retinal Dysfunctions
by Lorenzo Caruso, Matteo Fields, Erika Rimondi, Giorgio Zauli, Giovanna Longo, Annalisa Marcuzzi, Maurizio Previati, Arianna Gonelli, Enrico Zauli and Daniela Milani
Int. J. Mol. Sci. 2024, 25(4), 2124; https://doi.org/10.3390/ijms25042124 - 09 Feb 2024
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Abstract
The human retina is a complex anatomical structure that has no regenerative capacity. The pathogenesis of most retinopathies can be attributed to inflammation, with the activation of the inflammasome protein platform, and to the impact of oxidative stress on the regulation of apoptosis [...] Read more.
The human retina is a complex anatomical structure that has no regenerative capacity. The pathogenesis of most retinopathies can be attributed to inflammation, with the activation of the inflammasome protein platform, and to the impact of oxidative stress on the regulation of apoptosis and autophagy/mitophagy in retinal cells. In recent years, new therapeutic approaches to treat retinopathies have been investigated. Experimental data suggest that the secretome of mesenchymal cells could reduce oxidative stress, autophagy, and the apoptosis of retinal cells, and in turn, the secretome of the latter could induce changes in mesenchymal cells. Other studies have evidenced that noncoding (nc)RNAs might be new targets for retinopathy treatment and novel disease biomarkers since a correlation has been found between ncRNA levels and retinopathies. A new field to explore is the interaction observed between the ocular and intestinal microbiota; indeed, recent findings have shown that the alteration of gut microbiota seems to be linked to ocular diseases, suggesting a gut–eye axis. To explore new therapeutical strategies for retinopathies, it is important to use proper models that can mimic the complexity of the retina. In this context, retinal organoids represent a good model for the study of the pathophysiology of the retina. Full article
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Planned Papers

The below list represents only planned manuscripts. Some of these manuscripts have not been received by the Editorial Office yet. Papers submitted to MDPI journals are subject to peer-review.

Planned papers I: From metabolome to transcriptome in the pursuit of therapeutic targets for severe acute pancreatitis: A paradigm shift
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