Common SNCA Genetic Variants and Parkinson’s Disease Risk: A Systematic Review and Meta-Analysis
Abstract
1. Introduction
2. Methods
2.1. Study Selection
2.2. Data Extraction
2.3. Quality Assessment
2.4. Statistical Analysis
3. Results
3.1. SNP rs356165
3.2. SNP rs2583988
3.3. SNP rs356219
3.4. SNP rs11931074
4. Discussion
4.1. SNP rs356165
4.2. SNP rs2583988
4.3. SNP rs356219
4.4. SNP rs11931074
5. Strengths and Limitations
6. Implications and Future Directions
7. Conclusions
Supplementary Materials
Author Contributions
Funding
Institutional Review Board Statement
Informed Consent Statement
Data Availability Statement
Conflicts of Interest
Abbreviations
PD | Parkinson’s Disease |
SNP | Single-nucleotide polymorphisms |
PD-MCI | Parkinson’s disease-mild cognitive impairment |
GCTA | Genome-wide complex trait analysis |
GWAS | Genome-wide association studies |
OR | Odds ratios |
CI | Confidence interval |
NOS | Newcastle-Ottawa Scale |
PDD | Parkinson’s disease dementia |
AAO | Earlier age at onset |
3′ UTR | 3′ untranslated region |
iRBD | Idiopathic REM sleep behaviour disorder |
References
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SNP ID | Comparison | N | OR (95% CI) | p-Value 1 | Z | I-Square | p-Value 2 | Model |
---|---|---|---|---|---|---|---|---|
Allelic G vs. A | 8 | 1.25 (1.06, 1.46) | 0.0071 | 2.69 | 80.1% | <0.0001 | R | |
rs356165 | Dominant AG + GG vs. AA | 5 | 1.37 (1.21, 1.54) | <0.0001 | 5.17 | 7.8% | 0.3620 | F |
Recessive GG vs. AG + AA | 5 | 1.50 (1.31, 1.71) | <0.0001 | 5.85 | 0.0% | 0.8834 | F | |
Allelic: T vs. C | 7 | 1.22 (1.00, 1.48) | 0.0446 | 2.01 | 79.2% | <0.0001 | R | |
rs2583988 | Dominant TT + TC vs. CC | 3 | 1.14 (0.93, 1.40) | 0.2076 | 1.26 | 0.0% | 0.4163 | F |
Recessive TT vs. TC + CC | 3 | 1.31 (0.86, 2.01) | 0.2057 | 1.27 | 55.2% | 0.1070 | R | |
Allelic: G vs. A | 16 | 1.35 (1.22; 1.50) | <0.0001 | 5.74 | 80.7% | <0.0001 | R | |
rs356219 | Dominant: AG + GG vs. AA | 14 | 1.46 (1.29, 1.65) | <0.0001 | 6.10 | 51.8% | 0.0125 | R |
Recessive: GG vs. AG + AA | 14 | 1.69 (1.49, 1.91) | <0.0001 | 8.12 | 50.2% | 0.0164 | R | |
Allelic: T vs. G | 14 | 1.36 (1.30, 1.42) | <0.0001 | 13.03 | 13.7% | 0.3029 | F | |
rs11931074 | Dominant: TG + TT vs. GG | 9 | 1.49 (1.35, 1.66) | <0.0001 | 7.61 | 0.0% | 0.5477 | F |
Recessive: TT vs. TG + GG | 8 | 1.48 (1.28,1.70) | <0.0001 | 5.43 | 36.3% | 0.1390 | R |
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Mohammadi, R.; Shirazi, M.; Sadat-Madani, S.F.; Yeo Cheng Long, M.Z.; Singh, C.L.; Tan, J.Y.; Deng, X.; Hashemi Fard, S.M.; Ng, S.Y.E.; Ng, A.S.L.; et al. Common SNCA Genetic Variants and Parkinson’s Disease Risk: A Systematic Review and Meta-Analysis. Int. J. Mol. Sci. 2025, 26, 6001. https://doi.org/10.3390/ijms26136001
Mohammadi R, Shirazi M, Sadat-Madani SF, Yeo Cheng Long MZ, Singh CL, Tan JY, Deng X, Hashemi Fard SM, Ng SYE, Ng ASL, et al. Common SNCA Genetic Variants and Parkinson’s Disease Risk: A Systematic Review and Meta-Analysis. International Journal of Molecular Sciences. 2025; 26(13):6001. https://doi.org/10.3390/ijms26136001
Chicago/Turabian StyleMohammadi, Raziyeh, Mahdi Shirazi, Sayedeh Fatemeh Sadat-Madani, Matthew Zachary Yeo Cheng Long, Corrine Lee Singh, Jayne Y. Tan, Xiao Deng, Seyed Majid Hashemi Fard, Samuel Y. E. Ng, Adeline S. L. Ng, and et al. 2025. "Common SNCA Genetic Variants and Parkinson’s Disease Risk: A Systematic Review and Meta-Analysis" International Journal of Molecular Sciences 26, no. 13: 6001. https://doi.org/10.3390/ijms26136001
APA StyleMohammadi, R., Shirazi, M., Sadat-Madani, S. F., Yeo Cheng Long, M. Z., Singh, C. L., Tan, J. Y., Deng, X., Hashemi Fard, S. M., Ng, S. Y. E., Ng, A. S. L., Tan, L. C. S., & Saffari, S. E. (2025). Common SNCA Genetic Variants and Parkinson’s Disease Risk: A Systematic Review and Meta-Analysis. International Journal of Molecular Sciences, 26(13), 6001. https://doi.org/10.3390/ijms26136001