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The Chemistry of Natural Products and Their Cancer Applications

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: closed (31 December 2023) | Viewed by 1005

Special Issue Editors


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Guest Editor
Department of Pharmacology and Physiology, University of Zaragoza | UNIZAR, Zaragoza, Spain
Interests: metabolism; intestinal transport; metal on cancer treatment

E-Mail Website
Guest Editor
Department of Pharmacology and Physiology, Forensic and Legal Medicine, Veterinary Faculty, University of Zaragoza, Zaragoza, Spain
Interests: plant extracts; olive oil; encapsulation of plant extracts

Special Issue Information

Dear Colleagues,

The application of natural products for therapeutic purposes has been the basis of traditional medicine. These products, mainly extracted from plants, contain bioactive components with beneficial properties for health. Among these components are polyphenols, characterized by great antioxidant and anti-inflammatory power; thus, their application in diseases related to oxidative stress, such as cancer, should be taken into consideration. On the other hand, cancer is a highly prevalent disease in the Western world, and its prevention and treatment is an objective pursued by many researchers today. The extraction of natural chemical compounds from residues, mainly agro-food or forestry, could be very useful not only for their application as bio-functional foods to improve human health, but also in promoting circular economy and solving environmental problems.

This Special Issue may publish original research papers and reviews on aspects related to the chemistry of natural products in the prevention and treatment of cancer, as well as the modulators, targets and pathways involved in their therapeutic actions. Importantly, the exact active ingredient of plant extracts must be reported in the submitted research manuscripts, since papers describing the effects of mixed extraction from plants will not be accepted.

This Special Issue is led by Dr. Maria Jesus Rodriguez-Yoldi and assisted by our Guest Editor’s assistant editor, Dr. Javier Quero Bellido (Department of Pharmacology and Physiology, Forensic and Legal Medicine, Veterinary Faculty, University of Zaragoza, Zaragoza, Spain).

Dr. María Jesus Rodríguez-Yoldi
Dr. Javier Quero Bellido
Guest Editors

Manuscript Submission Information

Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All submissions that pass pre-check are peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.

Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • natural products chemistry
  • bioactive compounds
  • cancer

Published Papers (1 paper)

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Research

15 pages, 4696 KiB  
Article
Antineoplastic Activity of 9″-Lithospermic Acid Methyl Ester in Glioblastoma Cells
by Panagiota Tzitiridou, Vasiliki Zoi, Theodora Papagrigoriou, Diamanto Lazari, Chrissa Sioka, Georgios A. Alexiou and Athanassios P. Kyritsis
Int. J. Mol. Sci. 2024, 25(4), 2094; https://doi.org/10.3390/ijms25042094 - 8 Feb 2024
Viewed by 727
Abstract
To date, many potent compounds have been found which are derived from plants and herbs and possess anticancer properties due to their antioxidant effects. 9″-Lithospermic acid methyl ester is an effective natural compound derived from the Thymus thracicus Velen. It has been proven [...] Read more.
To date, many potent compounds have been found which are derived from plants and herbs and possess anticancer properties due to their antioxidant effects. 9″-Lithospermic acid methyl ester is an effective natural compound derived from the Thymus thracicus Velen. It has been proven that this compound has substantial properties in different diseases, but its effects in cancer have not been thoroughly evaluated. The aim of this work was to study the effects of 9″-Lithospermic acid methyl ester (9″-methyl lithospermate) in U87 and T98 glioblastoma cell lines. Its effects on cellular viability were assessed via Trypan Blue and Crystal Violet stains, the cell cycle analysis through flow cytometry, and cell migration by employing the scratch wound healing assay. The results demonstrated that 9″-methyl lithospermate was able to inhibit cellular proliferation, induce cellular death, and inhibit cell migration. Furthermore, these results were intensified by the addition of temozolomide, the most prominent chemotherapeutic drug in glioblastoma tumors. Further studies are needed to reproduce these findings in animal models and investigate if 9″-lithospermic acid methyl ester represents a potential new therapeutic addition for gliomas. Full article
(This article belongs to the Special Issue The Chemistry of Natural Products and Their Cancer Applications)
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