Nuclear Envelope Proteins

Dear Colleagues,

The nuclear envelope functionally separates the nucleoplasm from the cytoplasm. The nuclear envelope is composed of two lipid bilayers, the outer nuclear membrane, which is contiguous with the endoplasmic reticulum, and the inner nuclear membrane. Embedded within the nuclear envelope are the nuclear pore complexes, which provide bi-directional transport across the nuclear membrane. Underlying the inner nuclear membrane is a network of intermediate filament proteins named lamins, which provide nuclear structure and elasticity.

The outer and inner nuclear membranes are functionally distinct proteinaceous membranes. There are over 100 inner nuclear membrane proteins, many of which are cell-type specific. These proteins have diverse cellular roles, including regulation of nuclear structure, genomic organization, chromatin architecture, gene expression, the cell cycle, and cytoskeletal organization. Given these diverse roles, it is not surprising mutations in many of these proteins cause or have been linked to many different diseases.

This Special Issue on “Nuclear Envelope Proteins” will contain a selection of research and review articles covering all aspects of nuclear envelope protein structure and function and provide mechanistic insight into their function. Studies of nuclear envelope protein function as it relates to disease are also encouraged.

Dr. James M. Holaska
Guest Editor

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