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Open AccessArticle

Poly(3-Hydroxybutyrate)-Based Nanoparticles for Sorafenib and Doxorubicin Anticancer Drug Delivery

1
Institute of Materials and Environmental Chemistry, Research Centre for Natural Sciences, Magyar tudósok körútja 2, H-1117 Budapest, Hungary
2
Research Institute of Biomolecular and Chemical Engineering, Faculty of Engineering, University of Pannonia, Egyetem u. 10, H-8200 Veszprém, Hungary
3
Centre of Polymer and Carbon Materials Polish Academy of Sciences, 34, M. Curie-Skłodowskiej Str., 41-819 Zabrze, Poland
4
Department of Microbiology and Virology School of Pharmacy with the Division of Laboratory Medicine Medical University of Silesia, 4 Jagiellońska St., 41-200 Sosnowiec, Poland
*
Author to whom correspondence should be addressed.
Int. J. Mol. Sci. 2020, 21(19), 7312; https://doi.org/10.3390/ijms21197312
Received: 2 September 2020 / Revised: 29 September 2020 / Accepted: 1 October 2020 / Published: 3 October 2020
Dual drug-loaded nanotherapeutics can play an important role against the drug resistance and side effects of the single drugs. Doxorubicin and sorafenib were efficiently co-encapsulated by tailor-made poly([R,S]-3-hydroxybutyrate) (PHB) using an emulsion–solvent evaporation method. Subsequent poly(ethylene glycol) (PEG) conjugation onto nanoparticles was applied to make the nanocarriers stealth and to improve their drug release characteristics. Monodisperse PHB–sorafenib–doxorubicin nanoparticles had an average size of 199.3 nm, which was increased to 250.5 nm after PEGylation. The nanoparticle yield and encapsulation efficiencies of drugs decreased slightly in consequence of PEG conjugation. The drug release of the doxorubicin was beneficial, since it was liberated faster in a tumor-specific acidic environment than in blood plasma. The PEG attachment decelerated the release of both the doxorubicin and the sorafenib, however, the release of the latter drug remained still significantly faster with increased initial burst compared to doxorubicin. Nevertheless, the PEG–PHB copolymer showed more beneficial drug release kinetics in vitro in comparison with our recently developed PEGylated poly(lactic-co-glycolic acid) nanoparticles loaded with the same drugs. View Full-Text
Keywords: poly(3-hydroxybutyrate); sorafenib; doxorubicin; dual drug-loaded nanoparticles poly(3-hydroxybutyrate); sorafenib; doxorubicin; dual drug-loaded nanoparticles
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MDPI and ACS Style

Babos, G.; Rydz, J.; Kawalec, M.; Klim, M.; Fodor-Kardos, A.; Trif, L.; Feczkó, T. Poly(3-Hydroxybutyrate)-Based Nanoparticles for Sorafenib and Doxorubicin Anticancer Drug Delivery. Int. J. Mol. Sci. 2020, 21, 7312. https://doi.org/10.3390/ijms21197312

AMA Style

Babos G, Rydz J, Kawalec M, Klim M, Fodor-Kardos A, Trif L, Feczkó T. Poly(3-Hydroxybutyrate)-Based Nanoparticles for Sorafenib and Doxorubicin Anticancer Drug Delivery. International Journal of Molecular Sciences. 2020; 21(19):7312. https://doi.org/10.3390/ijms21197312

Chicago/Turabian Style

Babos, György; Rydz, Joanna; Kawalec, Michal; Klim, Magdalena; Fodor-Kardos, Andrea; Trif, László; Feczkó, Tivadar. 2020. "Poly(3-Hydroxybutyrate)-Based Nanoparticles for Sorafenib and Doxorubicin Anticancer Drug Delivery" Int. J. Mol. Sci. 21, no. 19: 7312. https://doi.org/10.3390/ijms21197312

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