Next Article in Journal
Acute Myeloid Leukemia Affects Mouse Sperm Parameters, Spontaneous Acrosome Reaction, and Fertility Capacity
Previous Article in Journal
Vitamin D Supplementation in Central Nervous System Demyelinating Disease—Enough Is Enough
Article Menu
Issue 1 (January-1) cover image

Export Article

Open AccessArticle
Int. J. Mol. Sci. 2019, 20(1), 217; https://doi.org/10.3390/ijms20010217

Evaluation of the Biological Behavior of a Gold Nanocore-Encapsulated Human Serum Albumin Nanoparticle ([email protected]) in a CT-26 Tumor/Ascites Mouse Model after Intravenous/Intraperitoneal Administration

1
Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University, Taipei 112, Taiwan
2
Radiotherapy, Department of Medical Imaging, Cheng Hsin General Hospital, Taipei 112, Taiwan
3
Institute of Nuclear Energy Research, Taoyuan 325, Taiwan
4
Shin Kong Wu Ho-Su memorial hospital, Taipei 111, Taiwan
5
Molecular and Genetic Imaging Core/Taiwan Mouse Clinic, National Comprehensive Mouse Phenotyping and Drug Testing Center, Taipei 115, Taiwan
6
Department of Nuclear Medicine and National PET/Cyclotron Center, Taipei Veterans General Hospital, Taipei 112, Taiwan
*
Authors to whom correspondence should be addressed.
Received: 21 November 2018 / Revised: 24 December 2018 / Accepted: 28 December 2018 / Published: 8 January 2019
  |  
PDF [3031 KB, uploaded 8 January 2019]
  |  

Abstract

Colorectal cancer is one of the major causes of cancer-related death in Taiwan and worldwide. Patients with peritoneal metastasis from colorectal cancer have reduced overall survival and poor prognosis. Hybrid protein-inorganic nanoparticle systems have displayed multifunctional applications in solid cancer theranostics. In this study, a gold nanocore-encapsulated human serum albumin nanoparticle ([email protected]), which is a hybrid protein-inorganic nanoparticle, and its radioactive surrogate 111In-labeled [email protected] (111[email protected]), were developed and their biological behaviors were investigated in a tumor/ascites mouse model. 111[email protected] was injected either intravenously (iv) or intraperitoneally (ip) in CT-26 tumor/ascites-bearing mice. After ip injection, a remarkable and sustained radioactivity retention in the abdomen was noticed, based on microSPECT images. After iv injection, however, most of the radioactivity was accumulated in the mononuclear phagocyte system. The results of biodistribution indicated that ip administration was significantly more effective in increasing intraperitoneal concentration and tumor accumulation than iv administration. The ratios of area under the curve (AUC) of the ascites and tumors in the ip-injected group to those in the iv-injected group was 93 and 20, respectively. This study demonstrated that the ip injection route would be a better approach than iv injections for applying gold-albumin nanoparticle in peritoneal metastasis treatment. View Full-Text
Keywords: Hybrid protein-inorganic nanoparticle; intravenous injection; intraperitoneal injection; tumor/ascites animal model Hybrid protein-inorganic nanoparticle; intravenous injection; intraperitoneal injection; tumor/ascites animal model
Figures

Graphical abstract

This is an open access article distributed under the Creative Commons Attribution License which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited (CC BY 4.0).
SciFeed

Share & Cite This Article

MDPI and ACS Style

Chen, C.-C.; Li, J.-J.; Guo, N.-H.; Chang, D.-Y.; Wang, C.-Y.; Chen, J.-T.; Lin, W.-J.; Chi, K.-H.; Lee, Y.-J.; Liu, R.-S.; Chen, C.-L.; Wang, H.-E. Evaluation of the Biological Behavior of a Gold Nanocore-Encapsulated Human Serum Albumin Nanoparticle ([email protected]) in a CT-26 Tumor/Ascites Mouse Model after Intravenous/Intraperitoneal Administration. Int. J. Mol. Sci. 2019, 20, 217.

Show more citation formats Show less citations formats

Note that from the first issue of 2016, MDPI journals use article numbers instead of page numbers. See further details here.

Related Articles

Article Metrics

Article Access Statistics

1

Comments

[Return to top]
Int. J. Mol. Sci. EISSN 1422-0067 Published by MDPI AG, Basel, Switzerland RSS E-Mail Table of Contents Alert
Back to Top