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The Role of Natural Products in Non-alcoholic Fatty Liver Disease

A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Bioactives and Nutraceuticals".

Deadline for manuscript submissions: 28 June 2024 | Viewed by 1830

Special Issue Editors


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Guest Editor
1. Nutrition and Obesity Group, Department of Nutrition and Food Science, Faculty of Pharmacy and Lucio Lascaray Research Center, University of the Basque Country (UPV/EHU), Vitoria, Spain
2. CIBER Fisiopatología Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain
3. BIOARABA Institute of Health, Vitoria-Gasteiz, Spain
Interests: obesity; liver steatosis; insulin resistance; bioactive compounds; mitochondria; autophagy
Special Issues, Collections and Topics in MDPI journals

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Guest Editor
1. Nutrition and Obesity Group, Department of Nutrition and Food Science, Faculty of Pharmacy, Lucio Lascaray Research Center, University of the Basque Country (UPV/EHU), 01006 Vitoria, Spain
2. CIBER Fisiopatología Obesidad y Nutrición, Instituto de Salud Carlos III, Madrid, Spain
3. BIOARABA Institute of Health, Vitoria-Gasteiz, Spain
Interests: molecular nutrition; nutritional and metabolic diseases; adipocytes; hepatocytes; lipogenesis; fat; inflammatory biomarkers; obesity; non-alcoholic fatty liver disease; insulin signaling; insulin; glucose metabolism; lipid metabolism; insulin resistance; adipogenesis; adipose tissue; liver
Special Issues, Collections and Topics in MDPI journals

Special Issue Information

Dear Colleagues,

Non-alcoholic fatty liver diseases (NAFLD) are a vast spectrum of different diseases that affect up to 30% of the adult population. It is related to several co-morbidities, such as type 2 diabetes and obesity. Moreover, it ranges from simple steatosis, considered a benign disease, to other diseases, such as steatohepatitis, liver cirrhosis and hepatocarcinoma.

Due to the lack of effective pharmacologic agents, the scientific community is looking for new treatments. The use of natural products has emerged as an alternative therapeutic for the treatment of hepatic diseases, including non-alcoholic fatty liver disease, due to its anti-inflammatory, antioxidant, antidiabetic, insulin-sensitizing, antiobesity, hypolipidemic, and hepatoprotective properties.

We are pleased to invite you to participate in this Special Issue, "The Role of Natural Products in Non-alcoholic Fatty Liver Disease", by presenting your most recent research or ideas focused on the molecular-level studies between NAFLD and natural products. Experimental papers and up-to-date review articles are all welcome.

Dr. Saioa Gómez-Zorita
Prof. Dr. María P. Portillo
Guest Editors

Manuscript Submission Information

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Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.

Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.

Keywords

  • fatty liver
  • steatosis
  • steatohepatitis
  • hepatocarcinoma
  • non-alcoholic fatty liver disease
  • inflammation
  • fibrosis
  • oxidative stress
  • liver injury
  • active biomolecules
  • natural products
  • food
  • precision nutrition

Published Papers (1 paper)

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Review

31 pages, 9580 KiB  
Review
Berberine Effects in Pre-Fibrotic Stages of Non-Alcoholic Fatty Liver Disease—Clinical and Pre-Clinical Overview and Systematic Review of the Literature
by Florentina Ionita-Radu, Cristina Patoni, Andreea Simona Nancoff, Flavius-Stefan Marin, Laura Gaman, Ana Bucurica, Calin Socol, Mariana Jinga, Madalina Dutu and Sandica Bucurica
Int. J. Mol. Sci. 2024, 25(8), 4201; https://doi.org/10.3390/ijms25084201 - 10 Apr 2024
Viewed by 1465
Abstract
Non-alcoholic fatty liver disease (NAFLD) is the predominant cause of chronic liver conditions, and its progression is marked by evolution to non-alcoholic steatosis, steatohepatitis, cirrhosis related to non-alcoholic steatohepatitis, and the potential occurrence of hepatocellular carcinoma. In our systematic review, we searched two [...] Read more.
Non-alcoholic fatty liver disease (NAFLD) is the predominant cause of chronic liver conditions, and its progression is marked by evolution to non-alcoholic steatosis, steatohepatitis, cirrhosis related to non-alcoholic steatohepatitis, and the potential occurrence of hepatocellular carcinoma. In our systematic review, we searched two databases, Medline (via Pubmed Central) and Scopus, from inception to 5 February 2024, and included 73 types of research (nine clinical studies and 64 pre-clinical studies) from 2854 published papers. Our extensive research highlights the impact of Berberine on NAFLD pathophysiology mechanisms, such as Adenosine Monophosphate-Activated Protein Kinase (AMPK), gut dysbiosis, peroxisome proliferator-activated receptor (PPAR), Sirtuins, and inflammasome. Studies involving human subjects showed a measurable reduction of liver fat in addition to improved profiles of serum lipids and hepatic enzymes. While current drugs for NAFLD treatment are either scarce or still in development or launch phases, Berberine presents a promising profile. However, improvements in its formulation are necessary to enhance the bioavailability of this natural substance. Full article
(This article belongs to the Special Issue The Role of Natural Products in Non-alcoholic Fatty Liver Disease)
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