Modelling Biological Barriers to Study Molecular Trafficking In Vitro: Advances and Applications
A special issue of International Journal of Molecular Sciences (ISSN 1422-0067). This special issue belongs to the section "Molecular Endocrinology and Metabolism".
Deadline for manuscript submissions: closed (30 November 2022) | Viewed by 18854
Special Issue Editors
Interests: nanomedicine; regenerative medicine; cell imaging; ageing; muscle atrophy/dystrophy; antioxidant processes
Special Issues, Collections and Topics in MDPI journals
Interests: nanomaterials; nanoparticles formulation and characterization; drug delivery; cell culture; tissue engineering; biomaterilas; molecular biology; biological barriers
Special Issues, Collections and Topics in MDPI journals
Special Issue Information
Dear Colleagues,
Understanding molecular traffic thought biological barriers is crucial for basic and applied research in several fields such as pharmaceutics, nanotechnology, pathology, physiology, toxicology, cosmetics, and food science. In recent years, a variety of in vitro models of biological barriers have been developed: the conventional two-dimensional cell monocultures have been complemented by three-dimensional co-cultures and organoids; to better mimic the barrier structure, bioengineered materials have been used to build matrices and scaffolds as a support for the cultured cells; bioreactors and microfluidics have made it possible to simulate the complex physiological dynamics that occurs in vivo. These models have proved to be standardized, reliable, fast, cost effective and ethically preferable, and allowed investigating how molecules may move through several types of barriers, such as the skin, cornea, intestinal mucosa, airway epithelium, renal epithelium, blood–brain and blood–placental barrier, and others.
This Special Issue is aimed at illustrating the great contribution of in vitro biological barriers to the knowledge of the trans-barrier molecular trafficking in vivo, as well as at presenting novel biological barrier models designed for permeability studies. All related deep molecular research is welcome and in vivo verification experiments are highly encouraged.
We invite researchers of all the relevant fields—bioengineering, biology, biotechnology, chemistry, pharmacology, biophysics, etc.—to present their results and commentaries by contributing original research articles or review papers.
Prof. Manuela Malatesta
Dr. Flavia Carton
Guest Editors
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Keywords
- barrier permeability
- cell culture
- biomaterials
- bioreactor
- microfluidics
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