Special Issue "Molecular Mechanisms of Sensorineural Hearing Loss and Development of Inner Ear Therapeutics"
Deadline for manuscript submissions: closed (31 October 2020).
Interests: auditory neuroscience; hearing; hearing loss; inner ear diseases; inner ear therapeutics; drug delivery to the inner ear; neuroprotection; purinergic signalling; adenosine receptors
According to the World Health Organisation, around 466 million people worldwide have disabling hearing loss and it is estimated that by 2050 this number will increase to 900 million. The vast majority of the hearing loss is sensorineural due to disease, degeneration or trauma to the cochlea of the inner ear. The etiology of sensorineural hearing loss (SNHL) is complex and multifactorial arising from congenital and acquired causes. Congenital hearing loss commonly manifests as hearing deficits at birth or during early development, while acquired hearing loss is usually sustained in later life as a result of infection, exposure to excessive noise, ototoxic drugs or progression with age (presbyacusis).
Substantial progress has been made in recent years towards understanding the underlying mechanisms of SNHL and the discovery of novel therapeutic targets to prevent and mitigate the hearing loss. In addition, the link between hearing loss and dementia has been established, with the view that hearing loss prevention may also protect cognitive function.
The aim of this special issue is to advance our understanding of the causes and mechanisms of hearing loss and propose novel strategies to protect and restore hearing. We invite investigators to contribute original research articles and review articles that will address the mechanisms of SNHL caused by cochlear injury or gene mutations, biomarkers of hearing loss, biological restoration of hearing and prevention of cognitive deficits associated with presbyacusis.
Potential topics include, but are not limited to:
• Molecular and cellular mechanisms of SNHL
• Age-related inflammaging in the inner ear
• Cochlear neuropathy and hidden hearing loss
• Genetic hearing loss
• Meniere’s disease and tinnitus
• Biomarkers of hearing loss
• The link between hearing loss and dementia
• Preservation of residual hearing after cochlear implantation
• Hair cell regeneration
• Cell-, drug-, and gene-based therapies to restore hearing
• Drug delivery to the inner ear
Dr. Srdjan M Vlajkovic
Manuscript Submission Information
Manuscripts should be submitted online at www.mdpi.com by registering and logging in to this website. Once you are registered, click here to go to the submission form. Manuscripts can be submitted until the deadline. All papers will be peer-reviewed. Accepted papers will be published continuously in the journal (as soon as accepted) and will be listed together on the special issue website. Research articles, review articles as well as short communications are invited. For planned papers, a title and short abstract (about 100 words) can be sent to the Editorial Office for announcement on this website.
Submitted manuscripts should not have been published previously, nor be under consideration for publication elsewhere (except conference proceedings papers). All manuscripts are thoroughly refereed through a single-blind peer-review process. A guide for authors and other relevant information for submission of manuscripts is available on the Instructions for Authors page. International Journal of Molecular Sciences is an international peer-reviewed open access semimonthly journal published by MDPI.
Please visit the Instructions for Authors page before submitting a manuscript. There is an Article Processing Charge (APC) for publication in this open access journal. For details about the APC please see here. Submitted papers should be well formatted and use good English. Authors may use MDPI's English editing service prior to publication or during author revisions.
- Mechanisms of hearing loss
- Biomarkers of hearing loss
- Therapeutic interventions for hearing loss
- Hearing loss and dementia