Chronic Oral Selegiline Treatment Mitigates Age-Related Hearing Loss in BALB/c Mice
Abstract
:1. Introduction
2. Results
2.1. Effect of Chronic Oral Administration of Selegiline on Hearing Function in BALB/c and DBA/2J Mice
2.1.1. Experiment I (0.15 and 1.5 mg/kg Selegiline)
2.1.2. Experiment II (4 and 15, 45 mg/kg Selegiline)
2.2. Effect of Chronic Oral Selegiline Administration on Water Intake, Body Weight and Survival Rate of BALB/c and DBA/2J Mice
2.2.1. Changes in Water Intake
2.2.2. Changes in Body Weight
2.2.3. Survival Rate
2.3. Effect of 4 mg/kg Selegiline on Locomotor Activity
3. Discussion
4. Materials and Methods
4.1. Ethics Statement
4.2. Experimental Animals and Housing Conditions
4.3. Experimental Design of Hearing Function Measurements and Selegiline Administration
4.4. Auditory Brainstem Response (ABR) Recordings
4.5. Survival Analysis
4.6. Test of Locomotor Activity
4.7. Data Analysis
Author Contributions
Funding
Acknowledgments
Conflicts of Interest
References
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Szepesy, J.; Humli, V.; Farkas, J.; Miklya, I.; Tímár, J.; Tábi, T.; Gáborján, A.; Polony, G.; Szirmai, Á.; Tamás, L.; et al. Chronic Oral Selegiline Treatment Mitigates Age-Related Hearing Loss in BALB/c Mice. Int. J. Mol. Sci. 2021, 22, 2853. https://doi.org/10.3390/ijms22062853
Szepesy J, Humli V, Farkas J, Miklya I, Tímár J, Tábi T, Gáborján A, Polony G, Szirmai Á, Tamás L, et al. Chronic Oral Selegiline Treatment Mitigates Age-Related Hearing Loss in BALB/c Mice. International Journal of Molecular Sciences. 2021; 22(6):2853. https://doi.org/10.3390/ijms22062853
Chicago/Turabian StyleSzepesy, Judit, Viktória Humli, János Farkas, Ildikó Miklya, Júlia Tímár, Tamás Tábi, Anita Gáborján, Gábor Polony, Ágnes Szirmai, László Tamás, and et al. 2021. "Chronic Oral Selegiline Treatment Mitigates Age-Related Hearing Loss in BALB/c Mice" International Journal of Molecular Sciences 22, no. 6: 2853. https://doi.org/10.3390/ijms22062853